Mesoporous Caged-γ-AlOOH-Double-Stranded RNA Analog Complexes for Cancer Immunotherapy

Xia Li, Mohamed A. Shenashen, Xiupeng Wang, Atsuo Ito, Akiyoshi Taniguchi, Sherif A. EI-Safty

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Alum exhibits the superior biocompatibility in the history of human healthcare, as the only FDA-approved inorganic adjuvant in most human vaccines. However, up to now, there are few reports about the in-depth research between its nanostructure and carrier properties in vitro and in vivo. In this study, the caged architecture of uniform mesoporous γ-AlOOH nanorods (MANRs) comprises realigned pores and open windows at the edges, 1D tubular tunnels, and oxyhydroxide layer that can serve as carriers for cancer immunotherapy. Compared with commercial alum, the MANRs exhibit a higher loading amount of a model cancer antigen and a stronger intracellular uptake by THP-1-differentiated macrophage-like cells in vitro. Compared with commercial alum and soluble ovalbumin, the MANRs loaded with a model cancer antigen, ovalbumi, and an immunopotentiator, double-stranded RNA analog poly(I:C) markedly increase the anticancer immunity and CD4+ and CD8+ T cell populations in mouse splenocytes in vivo. The MANRs are promising as an adjuvant substance in cancer immunotherapy for clinical use.

Original languageEnglish
Article number1700114
JournalAdvanced Biosystems
Volume2
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Fingerprint

Nanotubes
Double-Stranded RNA
RNA
Nanorods
Immunotherapy
Antigens
Neoplasms
Immunologic Adjuvants
Poly I-C
Vaccines
T-cells
Nanostructures
Macrophages
Ovalbumin
Biocompatibility
Immunity
Tunnels
History
Delivery of Health Care
T-Lymphocytes

Keywords

  • cancer antigen
  • cancer immunotherapy
  • intracellular uptake
  • mesoporous caged-γ-AlOOH nanorods

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biomaterials
  • Biomedical Engineering

Cite this

Mesoporous Caged-γ-AlOOH-Double-Stranded RNA Analog Complexes for Cancer Immunotherapy. / Li, Xia; Shenashen, Mohamed A.; Wang, Xiupeng; Ito, Atsuo; Taniguchi, Akiyoshi; EI-Safty, Sherif A.

In: Advanced Biosystems, Vol. 2, No. 1, 1700114, 01.01.2018.

Research output: Contribution to journalArticle

Li, Xia ; Shenashen, Mohamed A. ; Wang, Xiupeng ; Ito, Atsuo ; Taniguchi, Akiyoshi ; EI-Safty, Sherif A. / Mesoporous Caged-γ-AlOOH-Double-Stranded RNA Analog Complexes for Cancer Immunotherapy. In: Advanced Biosystems. 2018 ; Vol. 2, No. 1.
@article{9353dda05adb48e8a4aafa85b43607c4,
title = "Mesoporous Caged-γ-AlOOH-Double-Stranded RNA Analog Complexes for Cancer Immunotherapy",
abstract = "Alum exhibits the superior biocompatibility in the history of human healthcare, as the only FDA-approved inorganic adjuvant in most human vaccines. However, up to now, there are few reports about the in-depth research between its nanostructure and carrier properties in vitro and in vivo. In this study, the caged architecture of uniform mesoporous γ-AlOOH nanorods (MANRs) comprises realigned pores and open windows at the edges, 1D tubular tunnels, and oxyhydroxide layer that can serve as carriers for cancer immunotherapy. Compared with commercial alum, the MANRs exhibit a higher loading amount of a model cancer antigen and a stronger intracellular uptake by THP-1-differentiated macrophage-like cells in vitro. Compared with commercial alum and soluble ovalbumin, the MANRs loaded with a model cancer antigen, ovalbumi, and an immunopotentiator, double-stranded RNA analog poly(I:C) markedly increase the anticancer immunity and CD4+ and CD8+ T cell populations in mouse splenocytes in vivo. The MANRs are promising as an adjuvant substance in cancer immunotherapy for clinical use.",
keywords = "cancer antigen, cancer immunotherapy, intracellular uptake, mesoporous caged-γ-AlOOH nanorods",
author = "Xia Li and Shenashen, {Mohamed A.} and Xiupeng Wang and Atsuo Ito and Akiyoshi Taniguchi and EI-Safty, {Sherif A.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/adbi.201700114",
language = "English",
volume = "2",
journal = "Advanced Biosystems",
issn = "2366-7478",
publisher = "Wiley-VCH Verlag",
number = "1",

}

TY - JOUR

T1 - Mesoporous Caged-γ-AlOOH-Double-Stranded RNA Analog Complexes for Cancer Immunotherapy

AU - Li, Xia

AU - Shenashen, Mohamed A.

AU - Wang, Xiupeng

AU - Ito, Atsuo

AU - Taniguchi, Akiyoshi

AU - EI-Safty, Sherif A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Alum exhibits the superior biocompatibility in the history of human healthcare, as the only FDA-approved inorganic adjuvant in most human vaccines. However, up to now, there are few reports about the in-depth research between its nanostructure and carrier properties in vitro and in vivo. In this study, the caged architecture of uniform mesoporous γ-AlOOH nanorods (MANRs) comprises realigned pores and open windows at the edges, 1D tubular tunnels, and oxyhydroxide layer that can serve as carriers for cancer immunotherapy. Compared with commercial alum, the MANRs exhibit a higher loading amount of a model cancer antigen and a stronger intracellular uptake by THP-1-differentiated macrophage-like cells in vitro. Compared with commercial alum and soluble ovalbumin, the MANRs loaded with a model cancer antigen, ovalbumi, and an immunopotentiator, double-stranded RNA analog poly(I:C) markedly increase the anticancer immunity and CD4+ and CD8+ T cell populations in mouse splenocytes in vivo. The MANRs are promising as an adjuvant substance in cancer immunotherapy for clinical use.

AB - Alum exhibits the superior biocompatibility in the history of human healthcare, as the only FDA-approved inorganic adjuvant in most human vaccines. However, up to now, there are few reports about the in-depth research between its nanostructure and carrier properties in vitro and in vivo. In this study, the caged architecture of uniform mesoporous γ-AlOOH nanorods (MANRs) comprises realigned pores and open windows at the edges, 1D tubular tunnels, and oxyhydroxide layer that can serve as carriers for cancer immunotherapy. Compared with commercial alum, the MANRs exhibit a higher loading amount of a model cancer antigen and a stronger intracellular uptake by THP-1-differentiated macrophage-like cells in vitro. Compared with commercial alum and soluble ovalbumin, the MANRs loaded with a model cancer antigen, ovalbumi, and an immunopotentiator, double-stranded RNA analog poly(I:C) markedly increase the anticancer immunity and CD4+ and CD8+ T cell populations in mouse splenocytes in vivo. The MANRs are promising as an adjuvant substance in cancer immunotherapy for clinical use.

KW - cancer antigen

KW - cancer immunotherapy

KW - intracellular uptake

KW - mesoporous caged-γ-AlOOH nanorods

UR - http://www.scopus.com/inward/record.url?scp=85065054173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065054173&partnerID=8YFLogxK

U2 - 10.1002/adbi.201700114

DO - 10.1002/adbi.201700114

M3 - Article

VL - 2

JO - Advanced Biosystems

JF - Advanced Biosystems

SN - 2366-7478

IS - 1

M1 - 1700114

ER -