Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study

Mikhail F. Chernov, Kotaro Nakaya, Hidetoshi Kasuya, Koichi Kato, Yuko Ono, Shigetoshi Yoshida, Ryoichi Nakamura, Takashi Suzuki, Yoshihiro Muragaki, Hiroshi Iseki, Osami Kubo, Tomokatsu Hori, Kintomo Takakura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The objective of the present study was metabolic characterization of the peritumoral brain in the vicinity of meningiomas using proton magnetic resonance spectroscopy (1H-MRS). Data of long-echo (TR: 2000 ms, TE: 136 ms) single-voxel spectroscopic investigations were obtained during preoperative examination of 81 patients (19 men and 62 women; mean age, 56.5 years). Twenty-seven neoplasms were disclosed incidentally. Moderate-to-severe peritumoral edema was presented in 20 cases. Invasive growth of the tumor was macroscopically identified during surgery in 35 cases. Analyzed metabolites included N-acetylaspartate (NAA), choline-containing compounds (Cho), mobile lipids (Lip) and lactate (Lac). Compared to distant normal-appearing white matter 1H-MRS of the brain in the vicinity of meningiomas disclosed statistically significant decrease of NAA content (P = 0.0019). Investigated metabolic parameters depended on the presence of invasive tumor growth and prominent peritumoral edema, as well as on the size of the neoplasm, its location, and the patient's age. More severe 1H-MRS-detected peritumoral metabolic abnormalities associated with invasive growth of meningioma might be used for its prediction. The presence of meningioma-related neurological symptoms was mainly determined by the size of the tumor, while might be also associated with lower normalized NAA/Cho ratio and more frequent presence of a Lip peak in the peritumoral brain. In conclusion, decrease of NAA content constitutes the most prominent 1H-MRS-detected brain abnormality in the vicinity of intracranial meningiomas. Peritumoral spectroscopic alterations are determined by a variety of factors, can be predictive for invasive tumor growth and may correspond to presented neurological symptoms.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalJournal of the Neurological Sciences
Volume284
Issue number1-2
DOIs
Publication statusPublished - 2009 Sep 15
Externally publishedYes

Fingerprint

Meningioma
Brain
Neoplasms
Growth
Edema
Lipids
Choline
Proton Magnetic Resonance Spectroscopy
Lactic Acid
N-acetylaspartate

Keywords

  • Invasive growth
  • Meningioma
  • Metabolic alterations
  • Neurological symptoms
  • Peritumoral brain edema
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Chernov, M. F., Nakaya, K., Kasuya, H., Kato, K., Ono, Y., Yoshida, S., ... Takakura, K. (2009). Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study. Journal of the Neurological Sciences, 284(1-2), 168-174. https://doi.org/10.1016/j.jns.2009.05.015

Metabolic alterations in the peritumoral brain in cases of meningiomas : 1H-MRS study. / Chernov, Mikhail F.; Nakaya, Kotaro; Kasuya, Hidetoshi; Kato, Koichi; Ono, Yuko; Yoshida, Shigetoshi; Nakamura, Ryoichi; Suzuki, Takashi; Muragaki, Yoshihiro; Iseki, Hiroshi; Kubo, Osami; Hori, Tomokatsu; Takakura, Kintomo.

In: Journal of the Neurological Sciences, Vol. 284, No. 1-2, 15.09.2009, p. 168-174.

Research output: Contribution to journalArticle

Chernov, MF, Nakaya, K, Kasuya, H, Kato, K, Ono, Y, Yoshida, S, Nakamura, R, Suzuki, T, Muragaki, Y, Iseki, H, Kubo, O, Hori, T & Takakura, K 2009, 'Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study', Journal of the Neurological Sciences, vol. 284, no. 1-2, pp. 168-174. https://doi.org/10.1016/j.jns.2009.05.015
Chernov, Mikhail F. ; Nakaya, Kotaro ; Kasuya, Hidetoshi ; Kato, Koichi ; Ono, Yuko ; Yoshida, Shigetoshi ; Nakamura, Ryoichi ; Suzuki, Takashi ; Muragaki, Yoshihiro ; Iseki, Hiroshi ; Kubo, Osami ; Hori, Tomokatsu ; Takakura, Kintomo. / Metabolic alterations in the peritumoral brain in cases of meningiomas : 1H-MRS study. In: Journal of the Neurological Sciences. 2009 ; Vol. 284, No. 1-2. pp. 168-174.
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