Abstract
Immobilization induces abnormal bone metabolism and rapid decalcification. Measurements of bone mineral content disclosed rapid decalcification, especially in lumbar vertebral and metacarpal bones in our short-term 20-day bed rest study. Many factors could contribute to the marked demineralization. The activities of osteoclasts and osteoblasts were studied by following serum levels of tartrate-resistant acid phosphatase and alkaline phosphatase, biomarkers for osteocyte activity. There were no alterations in these enzymes during bed rest. However, urinary excretion of pyridinium cross-links, resorption markers of bone matrix itself, increased by day 10 with subsequent decrease at day 20. So decalcification was induced without any relation to osteoclast activity. As cytokines strongly modulate the function of osteoclasts, peripheral monocyte release of interleukin 1 α and tumor necrosis factor α were assayed to determine the contribution to this rapid demineralization. Cytokines were released transiently by day 7 and later rapidly decreased. However, there was no correlation between cytokine release and bone matrix resorption.
| Original language | English |
|---|---|
| Pages (from-to) | 37-41 |
| Number of pages | 5 |
| Journal | Acta Physiologica Scandinavica, Supplement |
| Volume | 150 |
| Issue number | 616 |
| Publication status | Published - 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
Cite this
Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. / Fukuoka, H.; Kiriyama, M.; Nishimura, Y.; Higurashi, M.; Suzuki, Y.; Gunji, A.
In: Acta Physiologica Scandinavica, Supplement, Vol. 150, No. 616, 1994, p. 37-41.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest
AU - Fukuoka, H.
AU - Kiriyama, M.
AU - Nishimura, Y.
AU - Higurashi, M.
AU - Suzuki, Y.
AU - Gunji, A.
PY - 1994
Y1 - 1994
N2 - Immobilization induces abnormal bone metabolism and rapid decalcification. Measurements of bone mineral content disclosed rapid decalcification, especially in lumbar vertebral and metacarpal bones in our short-term 20-day bed rest study. Many factors could contribute to the marked demineralization. The activities of osteoclasts and osteoblasts were studied by following serum levels of tartrate-resistant acid phosphatase and alkaline phosphatase, biomarkers for osteocyte activity. There were no alterations in these enzymes during bed rest. However, urinary excretion of pyridinium cross-links, resorption markers of bone matrix itself, increased by day 10 with subsequent decrease at day 20. So decalcification was induced without any relation to osteoclast activity. As cytokines strongly modulate the function of osteoclasts, peripheral monocyte release of interleukin 1 α and tumor necrosis factor α were assayed to determine the contribution to this rapid demineralization. Cytokines were released transiently by day 7 and later rapidly decreased. However, there was no correlation between cytokine release and bone matrix resorption.
AB - Immobilization induces abnormal bone metabolism and rapid decalcification. Measurements of bone mineral content disclosed rapid decalcification, especially in lumbar vertebral and metacarpal bones in our short-term 20-day bed rest study. Many factors could contribute to the marked demineralization. The activities of osteoclasts and osteoblasts were studied by following serum levels of tartrate-resistant acid phosphatase and alkaline phosphatase, biomarkers for osteocyte activity. There were no alterations in these enzymes during bed rest. However, urinary excretion of pyridinium cross-links, resorption markers of bone matrix itself, increased by day 10 with subsequent decrease at day 20. So decalcification was induced without any relation to osteoclast activity. As cytokines strongly modulate the function of osteoclasts, peripheral monocyte release of interleukin 1 α and tumor necrosis factor α were assayed to determine the contribution to this rapid demineralization. Cytokines were released transiently by day 7 and later rapidly decreased. However, there was no correlation between cytokine release and bone matrix resorption.
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M3 - Article
C2 - 8042523
AN - SCOPUS:0028093607
VL - 150
SP - 37
EP - 41
JO - Acta Physiologica Scandinavica, Supplement
JF - Acta Physiologica Scandinavica, Supplement
SN - 0302-2994
IS - 616
ER -