Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest

H. Fukuoka, M. Kiriyama, Y. Nishimura, M. Higurashi, Y. Suzuki, A. Gunji

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Immobilization induces abnormal bone metabolism and rapid decalcification. Measurements of bone mineral content disclosed rapid decalcification, especially in lumbar vertebral and metacarpal bones in our short-term 20-day bed rest study. Many factors could contribute to the marked demineralization. The activities of osteoclasts and osteoblasts were studied by following serum levels of tartrate-resistant acid phosphatase and alkaline phosphatase, biomarkers for osteocyte activity. There were no alterations in these enzymes during bed rest. However, urinary excretion of pyridinium cross-links, resorption markers of bone matrix itself, increased by day 10 with subsequent decrease at day 20. So decalcification was induced without any relation to osteoclast activity. As cytokines strongly modulate the function of osteoclasts, peripheral monocyte release of interleukin 1 α and tumor necrosis factor α were assayed to determine the contribution to this rapid demineralization. Cytokines were released transiently by day 7 and later rapidly decreased. However, there was no correlation between cytokine release and bone matrix resorption.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalActa Physiologica Scandinavica, Supplement
Volume150
Issue number616
Publication statusPublished - 1994
Externally publishedYes

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Bed Rest
Bone Remodeling
Osteoclasts
Monocytes
Bone Matrix
Cytokines
Osteocytes
Metacarpal Bones
Bone Resorption
Osteoblasts
Interleukin-1
Immobilization
Bone Density
Alkaline Phosphatase
Tumor Necrosis Factor-alpha
Biomarkers
Bone and Bones
Enzymes
Serum

ASJC Scopus subject areas

  • Physiology

Cite this

Fukuoka, H., Kiriyama, M., Nishimura, Y., Higurashi, M., Suzuki, Y., & Gunji, A. (1994). Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. Acta Physiologica Scandinavica, Supplement, 150(616), 37-41.

Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. / Fukuoka, H.; Kiriyama, M.; Nishimura, Y.; Higurashi, M.; Suzuki, Y.; Gunji, A.

In: Acta Physiologica Scandinavica, Supplement, Vol. 150, No. 616, 1994, p. 37-41.

Research output: Contribution to journalArticle

Fukuoka, H, Kiriyama, M, Nishimura, Y, Higurashi, M, Suzuki, Y & Gunji, A 1994, 'Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest', Acta Physiologica Scandinavica, Supplement, vol. 150, no. 616, pp. 37-41.
Fukuoka, H. ; Kiriyama, M. ; Nishimura, Y. ; Higurashi, M. ; Suzuki, Y. ; Gunji, A. / Metabolic turnover of bone and peripheral monocyte release of cytokines during short-term bed rest. In: Acta Physiologica Scandinavica, Supplement. 1994 ; Vol. 150, No. 616. pp. 37-41.
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