Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila

Gerrit Loch; Eva Jentgens; Margret Bülow; Ingo Zinke; Tetsushi Mori; Sayaka Suzuki; Haruko Takeyama; Michael Hoch

doi:10.1159/000346516

Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila

Gerrit Loch, Eva Jentgens, Margret Bülow, Ingo Zinke, Tetsushi Mori, Sayaka Suzuki, Haruko Takeyama, Michael Hoch^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.

Original language	English
Title of host publication	Innate Immunity
Subtitle of host publication	Resistance and Disease-Promoting Principles
Publisher	S. Karger AG
Pages	103-111
Number of pages	9
Volume	4
ISBN (Electronic)	9783318023480
ISBN (Print)	9783318023473
DOIs	https://doi.org/10.1159/000346516
Publication status	Published - 2013 Jun 5

ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1159/000346516

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abstract = "Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.",

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AU - Loch, Gerrit

AU - Jentgens, Eva

AU - Bülow, Margret

AU - Zinke, Ingo

AU - Mori, Tetsushi

AU - Suzuki, Sayaka

AU - Takeyama, Haruko

AU - Hoch, Michael

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AB - Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.

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Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila

Abstract

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