Metabolism and innate immunity

FOXO regulation of antimicrobial peptides in Drosophila

Gerrit Loch, Eva Jentgens, Margret Bülow, Ingo Zinke, Tetsushi Mori, Sayaka Suzuki, Haruko Takeyama, Michael Hoch

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.

    Original languageEnglish
    Title of host publicationInnate Immunity: Resistance and Disease-Promoting Principles
    PublisherS. Karger AG
    Pages103-111
    Number of pages9
    Volume4
    ISBN (Print)9783318023480, 9783318023473
    DOIs
    Publication statusPublished - 2013 Jun 5

    Fingerprint

    Innate Immunity
    Metabolism
    Drosophila
    Homeostasis
    Peptides
    Immune system
    Medical problems
    Nutrients
    Animals
    Metabolic Diseases
    Health
    Drosophila melanogaster
    Immune System
    Immunity
    Atherosclerosis
    Chronic Disease
    Processing
    Food

    ASJC Scopus subject areas

    • Medicine(all)
    • Immunology and Microbiology(all)
    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Loch, G., Jentgens, E., Bülow, M., Zinke, I., Mori, T., Suzuki, S., ... Hoch, M. (2013). Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila. In Innate Immunity: Resistance and Disease-Promoting Principles (Vol. 4, pp. 103-111). S. Karger AG. https://doi.org/10.1159/000346516

    Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in Drosophila. / Loch, Gerrit; Jentgens, Eva; Bülow, Margret; Zinke, Ingo; Mori, Tetsushi; Suzuki, Sayaka; Takeyama, Haruko; Hoch, Michael.

    Innate Immunity: Resistance and Disease-Promoting Principles. Vol. 4 S. Karger AG, 2013. p. 103-111.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Loch, G, Jentgens, E, Bülow, M, Zinke, I, Mori, T, Suzuki, S, Takeyama, H & Hoch, M 2013, Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila. in Innate Immunity: Resistance and Disease-Promoting Principles. vol. 4, S. Karger AG, pp. 103-111. https://doi.org/10.1159/000346516
    Loch G, Jentgens E, Bülow M, Zinke I, Mori T, Suzuki S et al. Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila. In Innate Immunity: Resistance and Disease-Promoting Principles. Vol. 4. S. Karger AG. 2013. p. 103-111 https://doi.org/10.1159/000346516
    Loch, Gerrit ; Jentgens, Eva ; Bülow, Margret ; Zinke, Ingo ; Mori, Tetsushi ; Suzuki, Sayaka ; Takeyama, Haruko ; Hoch, Michael. / Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in Drosophila. Innate Immunity: Resistance and Disease-Promoting Principles. Vol. 4 S. Karger AG, 2013. pp. 103-111
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