Metabolism and innate immunity: FOXO regulation of antimicrobial peptides in Drosophila

Gerrit Loch, Eva Jentgens, Margret Bülow, Ingo Zinke, Tetsushi Mori, Sayaka Suzuki, Haruko Takeyama, Michael Hoch

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.

    Original languageEnglish
    Title of host publicationInnate Immunity: Resistance and Disease-Promoting Principles
    PublisherS. Karger AG
    Pages103-111
    Number of pages9
    Volume4
    ISBN (Print)9783318023480, 9783318023473
    DOIs
    Publication statusPublished - 2013 Jun 5

    ASJC Scopus subject areas

    • Medicine(all)
    • Immunology and Microbiology(all)
    • Biochemistry, Genetics and Molecular Biology(all)

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