Abstract
Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.
| Original language | English |
|---|---|
| Title of host publication | Innate Immunity: Resistance and Disease-Promoting Principles |
| Publisher | S. Karger AG |
| Pages | 103-111 |
| Number of pages | 9 |
| Volume | 4 |
| ISBN (Print) | 9783318023480, 9783318023473 |
| DOIs | |
| Publication status | Published - 2013 Jun 5 |
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ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in Drosophila. / Loch, Gerrit; Jentgens, Eva; Bülow, Margret; Zinke, Ingo; Mori, Tetsushi; Suzuki, Sayaka; Takeyama, Haruko; Hoch, Michael.
Innate Immunity: Resistance and Disease-Promoting Principles. Vol. 4 S. Karger AG, 2013. p. 103-111.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Metabolism and innate immunity
T2 - FOXO regulation of antimicrobial peptides in Drosophila
AU - Loch, Gerrit
AU - Jentgens, Eva
AU - Bülow, Margret
AU - Zinke, Ingo
AU - Mori, Tetsushi
AU - Suzuki, Sayaka
AU - Takeyama, Haruko
AU - Hoch, Michael
PY - 2013/6/5
Y1 - 2013/6/5
N2 - Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.
AB - Metabolic homeostasis is fundamental for the development and the survival of animals. It requires the proper functioning of pathways that control the sensing and processing of nutrients, the storage and mobilization of energy. Recent data demonstrate that energy homeostasis and immune responses are tightly connected and that inaccurate metabolic regulation can adversely influence immune functions. Dysfunctions of the immune system have been demonstrated to underlie many chronic metabolic diseases, including diabetes, metabolic syndrome and atherosclerosis. The molecular mechanisms behind the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact.
UR - http://www.scopus.com/inward/record.url?scp=84925961839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925961839&partnerID=8YFLogxK
U2 - 10.1159/000346516
DO - 10.1159/000346516
M3 - Chapter
AN - SCOPUS:84925961839
SN - 9783318023480
SN - 9783318023473
VL - 4
SP - 103
EP - 111
BT - Innate Immunity: Resistance and Disease-Promoting Principles
PB - S. Karger AG
ER -