Metastability of supersaturated solution and nucleation

Noriaki Kubota, Masanori Kobari, Izumi Hirasawa

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    A certain time may elapse for the occurrence of a first nucleation after a solution is made supersaturated. Thus, the supersaturated solution looks as if it could be in a metastable state though in a limited time. Such metastability of a supersaturated solution has been evaluated (rather technically) by the magnitude of the metastable zone width (MSZW), i.e., the supercooling at which a first nucleation event is detected when supersaturation is increased by cooling, or the induction time, i.e., the time elapsed until a first nucleation event is detected at a constant temperature. The larger these values are, the higher themetastability is. Surprisingly, however, these two nucleation-related quantities are not clearly understood. There is still much confusion. This chapter provides an overview of recent understandings of the MSZW and induction time with focus on the problems of (1) stochastic and deterministic aspects, (2) time-dependent change of solution structure, (3) role of nucleation, and (4) relevance to the operation of an industrial batch crystallizer.

    Original languageEnglish
    Title of host publicationAdvances in Organic Crystal Chemistry: Comprehensive Reviews 2015
    PublisherSpringer Japan
    Pages115-138
    Number of pages24
    ISBN (Print)9784431555551, 9784431555544
    DOIs
    Publication statusPublished - 2015 Aug 6

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    Keywords

    • Crystallization
    • Induction time
    • Metastable zone width
    • Nucleation
    • Population balance model

    ASJC Scopus subject areas

    • Chemistry(all)
    • Engineering(all)
    • Physics and Astronomy(all)

    Cite this

    Kubota, N., Kobari, M., & Hirasawa, I. (2015). Metastability of supersaturated solution and nucleation. In Advances in Organic Crystal Chemistry: Comprehensive Reviews 2015 (pp. 115-138). Springer Japan. https://doi.org/10.1007/978-4-431-55555-1_7