Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models

Yuxuan Han, Kazushi Azuma, Shinya Watanabe, Kentaro Semba, Jun Nakayama*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Most studies on breast cancer metastasis have been performed using triple-negative breast cancer cells; thus, subtype-dependent metastatic ability of breast cancer is poorly understood. In this research, we performed intravenous injection (IVI) and intra-caudal arterial injections using nine human epidermal growth factor receptor-2 (HER2)-positive breast cancer cell lines for evaluating their metastatic abilities. Our results showed that MDA-MB-453, UACC-893, and HCC-202 had strong bone metastatic abilities, whereas HCC-2218 and HCC-1419 did not show bone metastasis. HER2-positive cell lines could hardly metastasize to the lung through IVI. From the genomic analysis, gene signatures were extracted according to the breast cancer subtypes and their metastatic preferences. The UACC-893 cell line was identified as a useful model for the metastasis study of HER2-positive breast cancer. Combined with our previous result on brain metastasis ability, we provide a characteristic metastasis profile of HER2-positive breast cancer cell lines in this study.

Original languageEnglish
Pages (from-to)467-477
Number of pages11
JournalClinical and Experimental Metastasis
Volume39
Issue number3
DOIs
Publication statusPublished - 2022 Jun

Keywords

  • Bone metastasis
  • HER2-positive breast cancer
  • In vivo imaging
  • Lung metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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