Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma

Yoshiki Mukudai, Meilin Zhang, Sunao Shiogama, Seiji Kondo, Chihiro Ito, Hiromi Motohashi, Kosuke Kato, Miharu Fujii, Satoru Shintani, Hideyuki Shigemori, Kazunaga Yazawa, Tatsuo Shirota

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy. However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required. The Paeoniaceae family is widely used in traditional Chinese medicine. We examined methanol and butanol extracts of Paeonia lutea (P. lutea) leaves for their potential as an anticancer agent. Both extracts decreased the proliferation of SCC cells, induced apoptotic cell death, and modulated migration, adhesion, chemotaxis, and haptotaxis in an extracellular matrix-(ECM-) dependent manner due to altered expression of several integrin subunits. Subsequently, SCC cells were subcutaneously transplanted into athymic nude mice; the extracts reduced the metastasis of SCC cells but had little effect on the volume of the primary tumor or survival or body weight of the mice. The results suggest that the extracts may hold promise for preventing cancer metastasis.

Original languageEnglish
Article number6087213
JournalEvidence-based Complementary and Alternative Medicine
Volume2016
DOIs
Publication statusPublished - 2016

Fingerprint

Paeonia
Butanols
Methanol
Squamous Cell Carcinoma
Neoplasm Metastasis
Chemotaxis
Nude Mice
Antineoplastic Agents
Poisons
Chinese Traditional Medicine
Head and Neck Neoplasms
Tumor Burden
Integrins
Extracellular Matrix
Cell Death
Radiotherapy
Body Weight
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. / Mukudai, Yoshiki; Zhang, Meilin; Shiogama, Sunao; Kondo, Seiji; Ito, Chihiro; Motohashi, Hiromi; Kato, Kosuke; Fujii, Miharu; Shintani, Satoru; Shigemori, Hideyuki; Yazawa, Kazunaga; Shirota, Tatsuo.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2016, 6087213, 2016.

Research output: Contribution to journalArticle

Mukudai, Y, Zhang, M, Shiogama, S, Kondo, S, Ito, C, Motohashi, H, Kato, K, Fujii, M, Shintani, S, Shigemori, H, Yazawa, K & Shirota, T 2016, 'Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma', Evidence-based Complementary and Alternative Medicine, vol. 2016, 6087213. https://doi.org/10.1155/2016/6087213
Mukudai, Yoshiki ; Zhang, Meilin ; Shiogama, Sunao ; Kondo, Seiji ; Ito, Chihiro ; Motohashi, Hiromi ; Kato, Kosuke ; Fujii, Miharu ; Shintani, Satoru ; Shigemori, Hideyuki ; Yazawa, Kazunaga ; Shirota, Tatsuo. / Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. In: Evidence-based Complementary and Alternative Medicine. 2016 ; Vol. 2016.
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AU - Kondo, Seiji

AU - Ito, Chihiro

AU - Motohashi, Hiromi

AU - Kato, Kosuke

AU - Fujii, Miharu

AU - Shintani, Satoru

AU - Shigemori, Hideyuki

AU - Yazawa, Kazunaga

AU - Shirota, Tatsuo

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