Method of ranking of heart valve characteristics at mitral position based on statistical model analysis

Makoto Arita, Kiyotaka Iwasaki, Mitsuo Umezu, Masanori Yoshida, Tetsuo Fujimoto, Hisayoshi Suma, Tadashi Isomura

    Research output: Contribution to journalArticle

    Abstract

    The purpose of this study was to explore a valve selection criterion based on the impact force generated at valve closure, and to test a statistical mathematical model for comparing valve performance. The impact force generated at valve closure in the mitral position was measured continuously, using a load cell mounted in the left atrial section of a mock circulatory system. Eight clinical valves were tested. The data obtained from the in vitro test were subjected to multiregression analysis, to enable systematic comparison of the impact forces of these valves. Furthermore, class I quantification theory was applied to construct the statistical mathematical model. As a result, the following interaction effect was observed in the statistical model. (1) The impact force generated at valve closure had a lower value in valves of smaller diameter. (2) The ranking of 29-mm-diameter valves by impact force was different for the flow region. Under the physiological flow condition of 4-61/min, high impact forces were generated in all valves, in the order Björk-Shiley monostrut, ATS, St. Jude medical, CarboMedics. We consider that low impact force at valve closure is desirable, upon consideration of the influence on the annulus tissue at valve replacement. From these findings, the results of the multiregression analysis provide indications for choosing the optimal valve for patients with severe mitral insufficiency (MI).

    Original languageEnglish
    Pages (from-to)131-137
    Number of pages7
    JournalJournal of Artificial Organs
    Volume4
    Issue number2
    Publication statusPublished - 2001

    Fingerprint

    Heart Valves
    Statistical Models
    Mathematical models
    Theoretical Models
    Mitral Valve Insufficiency
    Tissue
    Cardiovascular System
    Patient Selection

    Keywords

    • Impact force
    • In vitro test
    • Prosthetic heart valve
    • Quantification theory

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Method of ranking of heart valve characteristics at mitral position based on statistical model analysis. / Arita, Makoto; Iwasaki, Kiyotaka; Umezu, Mitsuo; Yoshida, Masanori; Fujimoto, Tetsuo; Suma, Hisayoshi; Isomura, Tadashi.

    In: Journal of Artificial Organs, Vol. 4, No. 2, 2001, p. 131-137.

    Research output: Contribution to journalArticle

    Arita, Makoto ; Iwasaki, Kiyotaka ; Umezu, Mitsuo ; Yoshida, Masanori ; Fujimoto, Tetsuo ; Suma, Hisayoshi ; Isomura, Tadashi. / Method of ranking of heart valve characteristics at mitral position based on statistical model analysis. In: Journal of Artificial Organs. 2001 ; Vol. 4, No. 2. pp. 131-137.
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    AU - Arita, Makoto

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    AU - Yoshida, Masanori

    AU - Fujimoto, Tetsuo

    AU - Suma, Hisayoshi

    AU - Isomura, Tadashi

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