TY - JOUR
T1 - Microbial circadian oscillatory systems in Neurospora and Synechococcus
T2 - Models for cellular clocks
AU - Iwasaki, H. Hideo
AU - Dunlap, J. C.Jay C.
N1 - Funding Information:
H Iwasaki thanks T Kondo, M Ishiura, and S Golden for discussion and sharing unpublished results, and CH Johnson and members of the Kondo lab for helpful discussion. H Iwasaki is supported by Japan Society for Promotion of Science for young scientist (JSPS; 09001517). JC Dunlap gratefully acknowledges insightful discussion and feedback from members of the Dartmouth rhythms community, especially J Loros, and was supported by grants from the National Institutes of Health (GM 34985, MH01186 and MH44651) and the Norris Cotton Cancer Center core grant at Dartmouth Medical School.
PY - 2000/4/1
Y1 - 2000/4/1
N2 - Common regulatory patterns have emerged among the feedback loops lying within circadian systems. Significant progress in dissecting the mechanism of clock resetting by temperature and the role of the WC proteins in the Neurospora light response has accompanied documentation of the importance of nuclear localization and phosphorylation-induced turnover of FRQ to this circadian cycle. The long-awaited molecular description of a transcription/translation loop in the Synechococcus circadian system represents a quantal step forward, followed by the identification of additional important proteins and interactions. Finally, the adaptive significance of rhythms in Synechococcus and by extension in all clocks nicely ties up an extraordinary year.
AB - Common regulatory patterns have emerged among the feedback loops lying within circadian systems. Significant progress in dissecting the mechanism of clock resetting by temperature and the role of the WC proteins in the Neurospora light response has accompanied documentation of the importance of nuclear localization and phosphorylation-induced turnover of FRQ to this circadian cycle. The long-awaited molecular description of a transcription/translation loop in the Synechococcus circadian system represents a quantal step forward, followed by the identification of additional important proteins and interactions. Finally, the adaptive significance of rhythms in Synechococcus and by extension in all clocks nicely ties up an extraordinary year.
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U2 - 10.1016/S1369-5274(00)00074-6
DO - 10.1016/S1369-5274(00)00074-6
M3 - Review article
C2 - 10744993
AN - SCOPUS:0034026033
VL - 3
SP - 189
EP - 196
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 2
ER -
