Microbioassay of nystatin with a yeast electrode

Isao Karube; Tadashi Matsunaga; Shuichi Suzuki

doi:10.1016/S0003-2670(01)84224-0

Microbioassay of nystatin with a yeast electrode

Isao Karube^*, Tadashi Matsunaga, Shuichi Suzuki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Microbioassay of nystatin is achieved with an electrode composed of a yeast membrane and an oxygen electrode, based on the inhibitory action of the antibiotic on the respiration of the yeast. A linear relationship is obtained between the rate of current increase and the potency of nystatin. The minimum measurable nystatin concentration is 0.5 unit ml-1.The assay takes less than l h; the standard deviation is 1.2 unit ml^-1 at the 27 USP unit ml^-1 level.

Original language	English
Pages (from-to)	39-44
Number of pages	6
Journal	Analytica Chimica Acta
Volume	109
Issue number	1
DOIs	https://doi.org/10.1016/S0003-2670(01)84224-0
Publication status	Published - 1979 Aug 1
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Analytical Chemistry
Spectroscopy
Environmental Chemistry

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AB - Microbioassay of nystatin is achieved with an electrode composed of a yeast membrane and an oxygen electrode, based on the inhibitory action of the antibiotic on the respiration of the yeast. A linear relationship is obtained between the rate of current increase and the potency of nystatin. The minimum measurable nystatin concentration is 0.5 unit ml-1.The assay takes less than l h; the standard deviation is 1.2 unit ml-1 at the 27 USP unit ml-1 level.

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Microbioassay of nystatin with a yeast electrode

Abstract

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