Microfluidic analysis of neurodegenerative impact evoked by local stimulation-triggered apoptotic information

Yoshikuni Edagawa, Taku Watanabe, Masaru Fujii, Kentaro Kawai, Shuichi Shoji

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Microfluidic analysis system for microscopic pharmacology handling single cells was demonstrated in this paper, which included the stimulation only on a local area of the target cell by using the laminar flowing of drug solutions and the systemic monitoring of the effect evoked on the whole cell. By this system, it was first elucidated that the stimulation of the tip of neurite with an apoptosis-inducing drug resulted in the expression of an apoptotic marker in the cell body as a remote position from the stimulated point. This indicates a new paradigm of microscopic pharmacology opens up here.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1511-1513
Number of pages3
Publication statusPublished - 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Keywords

  • Apoptosis
  • Micropharmacology
  • Neurite transmission
  • Neurodegeneration
  • Single cell

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Edagawa, Y., Watanabe, T., Fujii, M., Kawai, K., & Shoji, S. (2011). Microfluidic analysis of neurodegenerative impact evoked by local stimulation-triggered apoptotic information. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1511-1513). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 3).