Microfluidic synthesis of chiral salen Mn(ii) and Co(ii) complexes containing lysozyme

Daiki Tanaka, Wataru Kawakubo, Erika Tsuda, Yuya Mitsumoto, Dong Hyun Yoon, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Efficient microfluidic synthesis of chiral salen Mn(ii) and Co(ii) complexes containing lysozyme was achieved. The reaction conditions for the delicate protein were controlled precisely with a separation barrier in the microfluidic device. The microfluidic method has the following advantages over the conventional method: a remarkable reduction in the reaction time from 4.5 h to less than 1 s for the synthesis of Mn(ii) and Co(ii) complexes, a reduction in the reaction temperature from 40 to 23 °C, and no need for an N2 atmosphere because all the reagents are isolated from the air. A three-fold yield improvement was achieved for Mn(ii) and Co(ii) complexes containing lysozyme compared with conventional synthesis.

Original languageEnglish
Pages (from-to)81862-81868
Number of pages7
JournalRSC Advances
Volume6
Issue number85
DOIs
Publication statusPublished - 2016 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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