Microfluidics assisted synthesis of well-defined spherical polymeric microcapsules and their utilization as potential encapsulants

Sinoj Abraham, Eun Ho Jeong, Takahiro Arakawa, Shuichi Shoji, Kyung Chun Kim, Il Kim, Jeung Sang Go

    Research output: Contribution to journalArticle

    54 Citations (Scopus)

    Abstract

    In this article, the development of a novel technique to fabricate spherical polymeric microcapsules by utilizing microfluidic technology is presented. Atom transfer radical polymerization (ATRP) was employed to synthesize well-defined amphiphilic block copolymers. An organic polymer solution was constrained to adopt the spherical droplets in a continuous water phase at a T-junction microchannel, and the generation of the droplets was studied quantitatively. The flow conditions of two immiscible solutions were adjusted for the successful generation of the polymer droplets. The morphology of the microcapsules was examined. The efficiency of these polymer microcapsules as containers for the storage and controlled release of loaded molecules was evaluated by encapsulating the microcapsules with Congo-red dye and investigating the release performance using temperature controlled UV-VIS spectroscopy.

    Original languageEnglish
    Pages (from-to)752-756
    Number of pages5
    JournalLab on a Chip - Miniaturisation for Chemistry and Biology
    Volume6
    Issue number6
    DOIs
    Publication statusPublished - 2006

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    ASJC Scopus subject areas

    • Clinical Biochemistry

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