Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

Original languageEnglish
Pages (from-to)1699-1705
Number of pages7
JournalAdvanced Materials
Volume26
Issue number11
DOIs
Publication statusPublished - 2014 Mar 19

Keywords

  • cell delivery
  • magnetic nanoparticles (MNP)
  • retinal pigment epithelium (RPE)
  • tight junctions
  • ultrathin films (nanosheets)

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Medicine(all)

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  • Cite this

    Fujie, T., Mori, Y., Ito, S., Nishizawa, M., Bae, H., Nagai, N., Onami, H., Abe, T., Khademhosseini, A., & Kaji, H. (2014). Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer. Advanced Materials, 26(11), 1699-1705. https://doi.org/10.1002/adma.201304183