MicroRNAs in skeletal muscle

Takayuki Akimoto, Shuji Sawada

Research output: Contribution to journalReview article

Abstract

Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbid-ity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discov-ery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in deg-radation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
Journaljapanese journal of physical fitness and sports medicine
Volume61
Issue number1
DOIs
Publication statusPublished - 2012 Feb
Externally publishedYes

Keywords

  • Exercise
  • Training
  • Transcription
  • Translation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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