Microscale characterization of a mechanically adaptive polymer nanocomposite with cotton-derived cellulose nanocrystals for implantable BioMEMS

Allison E. Hess-Dunning, Dustin J. Tyler, James P. Harris, Jeffrey R. Capadona, Christoph Weder, Stuart J. Rowan, Christian A. Zorman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A mechanically adaptive polymer nanocomposite for use as a structural material for microelectromechanical system (MEMS)-based penetrating implantable biosensors, particularly for the brain, is presented as a solution to the limited clinical implementation of such sensors. Micromechanical testing of MEMS-scale test structures was used to determine the Young's moduli of the polymer nanocomposite in both its dry rigid state (E=2414MPa) and its wet compliant state (E=4.9 MPa), as well as the rate of mechanical switching upon immersion in an aqueous solution. The softening of the composite materials after implantation in the cortex of a Sprague-Dawley rat was studied by ex vivo environmentally controlled microtensile testing. A microfabrication process for producing metallized neural probes for recording of electrical signals was also developed. The results support the mechanically adaptive nanocomposite as a viable option for MEMS-based penetrating implantable biosensors.

Original languageEnglish
Article number6838966
Pages (from-to)774-784
Number of pages11
JournalJournal of Microelectromechanical Systems
Volume23
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

BioMEMS
Nanocrystals
Cotton
MEMS
Cellulose
Nanocomposites
Biosensors
Polymers
Microfabrication
Testing
Rats
Brain
Elastic moduli
Sensors
Composite materials

Keywords

  • Implantable biomedical devices
  • materials testing
  • nanocomposites
  • neural microtechnology
  • neural prosthesis
  • polymer films.

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering

Cite this

Microscale characterization of a mechanically adaptive polymer nanocomposite with cotton-derived cellulose nanocrystals for implantable BioMEMS. / Hess-Dunning, Allison E.; Tyler, Dustin J.; Harris, James P.; Capadona, Jeffrey R.; Weder, Christoph; Rowan, Stuart J.; Zorman, Christian A.

In: Journal of Microelectromechanical Systems, Vol. 23, No. 4, 6838966, 2014, p. 774-784.

Research output: Contribution to journalArticle

Hess-Dunning, Allison E. ; Tyler, Dustin J. ; Harris, James P. ; Capadona, Jeffrey R. ; Weder, Christoph ; Rowan, Stuart J. ; Zorman, Christian A. / Microscale characterization of a mechanically adaptive polymer nanocomposite with cotton-derived cellulose nanocrystals for implantable BioMEMS. In: Journal of Microelectromechanical Systems. 2014 ; Vol. 23, No. 4. pp. 774-784.
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