Abstract
A mechanically adaptive polymer nanocomposite for use as a structural material for microelectromechanical system (MEMS)-based penetrating implantable biosensors, particularly for the brain, is presented as a solution to the limited clinical implementation of such sensors. Micromechanical testing of MEMS-scale test structures was used to determine the Young's moduli of the polymer nanocomposite in both its dry rigid state (E=2414MPa) and its wet compliant state (E=4.9 MPa), as well as the rate of mechanical switching upon immersion in an aqueous solution. The softening of the composite materials after implantation in the cortex of a Sprague-Dawley rat was studied by ex vivo environmentally controlled microtensile testing. A microfabrication process for producing metallized neural probes for recording of electrical signals was also developed. The results support the mechanically adaptive nanocomposite as a viable option for MEMS-based penetrating implantable biosensors.
| Original language | English |
|---|---|
| Article number | 6838966 |
| Pages (from-to) | 774-784 |
| Number of pages | 11 |
| Journal | Journal of Microelectromechanical Systems |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Implantable biomedical devices
- materials testing
- nanocomposites
- neural microtechnology
- neural prosthesis
- polymer films.
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Mechanical Engineering
Cite this
Microscale characterization of a mechanically adaptive polymer nanocomposite with cotton-derived cellulose nanocrystals for implantable BioMEMS. / Hess-Dunning, Allison E.; Tyler, Dustin J.; Harris, James P.; Capadona, Jeffrey R.; Weder, Christoph; Rowan, Stuart J.; Zorman, Christian A.
In: Journal of Microelectromechanical Systems, Vol. 23, No. 4, 6838966, 2014, p. 774-784.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microscale characterization of a mechanically adaptive polymer nanocomposite with cotton-derived cellulose nanocrystals for implantable BioMEMS
AU - Hess-Dunning, Allison E.
AU - Tyler, Dustin J.
AU - Harris, James P.
AU - Capadona, Jeffrey R.
AU - Weder, Christoph
AU - Rowan, Stuart J.
AU - Zorman, Christian A.
PY - 2014
Y1 - 2014
N2 - A mechanically adaptive polymer nanocomposite for use as a structural material for microelectromechanical system (MEMS)-based penetrating implantable biosensors, particularly for the brain, is presented as a solution to the limited clinical implementation of such sensors. Micromechanical testing of MEMS-scale test structures was used to determine the Young's moduli of the polymer nanocomposite in both its dry rigid state (E=2414MPa) and its wet compliant state (E=4.9 MPa), as well as the rate of mechanical switching upon immersion in an aqueous solution. The softening of the composite materials after implantation in the cortex of a Sprague-Dawley rat was studied by ex vivo environmentally controlled microtensile testing. A microfabrication process for producing metallized neural probes for recording of electrical signals was also developed. The results support the mechanically adaptive nanocomposite as a viable option for MEMS-based penetrating implantable biosensors.
AB - A mechanically adaptive polymer nanocomposite for use as a structural material for microelectromechanical system (MEMS)-based penetrating implantable biosensors, particularly for the brain, is presented as a solution to the limited clinical implementation of such sensors. Micromechanical testing of MEMS-scale test structures was used to determine the Young's moduli of the polymer nanocomposite in both its dry rigid state (E=2414MPa) and its wet compliant state (E=4.9 MPa), as well as the rate of mechanical switching upon immersion in an aqueous solution. The softening of the composite materials after implantation in the cortex of a Sprague-Dawley rat was studied by ex vivo environmentally controlled microtensile testing. A microfabrication process for producing metallized neural probes for recording of electrical signals was also developed. The results support the mechanically adaptive nanocomposite as a viable option for MEMS-based penetrating implantable biosensors.
KW - Implantable biomedical devices
KW - materials testing
KW - nanocomposites
KW - neural microtechnology
KW - neural prosthesis
KW - polymer films.
UR - http://www.scopus.com/inward/record.url?scp=84905644799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905644799&partnerID=8YFLogxK
U2 - 10.1109/JMEMS.2014.2327035
DO - 10.1109/JMEMS.2014.2327035
M3 - Article
AN - SCOPUS:84905644799
VL - 23
SP - 774
EP - 784
JO - Journal of Microelectromechanical Systems
JF - Journal of Microelectromechanical Systems
SN - 1057-7157
IS - 4
M1 - 6838966
ER -