Microtechnologies to fuel neurobiological research with nanometer precision

Cecilia A. Brunello, Ville Jokinen, Prasanna Sakha, Hideyuki Terazono, Fumimasa Nomura, Tomoyuki Kaneko, Sari E. Lauri, Sami Franssila, Claudio Rivera, Kenji Yasuda, Henri J. Huttunen

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

The interface between engineering and molecular life sciences has been fertile ground for advancing our understanding of complex biological systems. Engineered microstructures offer a diverse toolbox for cellular and molecular biologists to direct the placement of cells and small organisms, and to recreate biological functions in vitro: cells can be positioned and connected in a designed fashion, and connectivity and community effects of cells studied. Because of the highly polar morphology and finely compartmentalized functions of neurons, microfabricated cell culture systems and related on-chip technologies have become an important enabling platform for studying development, function and degeneration of the nervous system at the molecular and cellular level. Here we review some of the compartmentalization techniques developed so far to highlight how high-precision control of neuronal connectivity allows new approaches for studying axonal and synaptic biology.

Original languageEnglish
Article number11
JournalJournal of Nanobiotechnology
Volume11
Issue number1
DOIs
Publication statusPublished - 2013 Apr 10
Externally publishedYes

Fingerprint

Microtechnology
Research
Biological Science Disciplines
Neurology
Biological systems
Cell culture
Nervous System
Neurons
Cell Culture Techniques
Technology
Microstructure

Keywords

  • Axonal transport
  • Connectivity
  • Electrophysiology
  • Microfabrication
  • Microfluidics
  • Micropatterning
  • Neurobiology
  • Neurodegeneration
  • On-chip technology
  • Plasticity
  • Synaptogenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Applied Microbiology and Biotechnology
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

Brunello, C. A., Jokinen, V., Sakha, P., Terazono, H., Nomura, F., Kaneko, T., ... Huttunen, H. J. (2013). Microtechnologies to fuel neurobiological research with nanometer precision. Journal of Nanobiotechnology, 11(1), [11]. https://doi.org/10.1186/1477-3155-11-11

Microtechnologies to fuel neurobiological research with nanometer precision. / Brunello, Cecilia A.; Jokinen, Ville; Sakha, Prasanna; Terazono, Hideyuki; Nomura, Fumimasa; Kaneko, Tomoyuki; Lauri, Sari E.; Franssila, Sami; Rivera, Claudio; Yasuda, Kenji; Huttunen, Henri J.

In: Journal of Nanobiotechnology, Vol. 11, No. 1, 11, 10.04.2013.

Research output: Contribution to journalReview article

Brunello, CA, Jokinen, V, Sakha, P, Terazono, H, Nomura, F, Kaneko, T, Lauri, SE, Franssila, S, Rivera, C, Yasuda, K & Huttunen, HJ 2013, 'Microtechnologies to fuel neurobiological research with nanometer precision', Journal of Nanobiotechnology, vol. 11, no. 1, 11. https://doi.org/10.1186/1477-3155-11-11
Brunello CA, Jokinen V, Sakha P, Terazono H, Nomura F, Kaneko T et al. Microtechnologies to fuel neurobiological research with nanometer precision. Journal of Nanobiotechnology. 2013 Apr 10;11(1). 11. https://doi.org/10.1186/1477-3155-11-11
Brunello, Cecilia A. ; Jokinen, Ville ; Sakha, Prasanna ; Terazono, Hideyuki ; Nomura, Fumimasa ; Kaneko, Tomoyuki ; Lauri, Sari E. ; Franssila, Sami ; Rivera, Claudio ; Yasuda, Kenji ; Huttunen, Henri J. / Microtechnologies to fuel neurobiological research with nanometer precision. In: Journal of Nanobiotechnology. 2013 ; Vol. 11, No. 1.
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