Mitochondrial macrohaplogroup associated with muscle power in healthy adults

N. Fuku*, H. Murakami, M. Iemitsu, K. Sanada, M. Tanaka, M. Miyachi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The present study was undertaken to examine the effect of mitochondrial haplogroups on aerobic and anaerobic performance phenotypes such as maximum oxygen consumption, muscle power, and muscle mass. We recruited 474 healthy Japanese individuals and measured their physical performance phenotypes such as peak oxygen uptake, muscle power, and muscle mass. The genotypes for 186 polymorphisms in the mitochondrial DNA were determined, and the haplotypes were classified into 2 macrohaplogroups (i. e., N and M) and 12 haplogroups (i. e., F, B, A, N9a, N9b, M7a, M7b, G1, G2, D4a, D4b, and D5). When we compared the 2 major Japanese macrohaplogroups, leg extension power (P=0.0395), leg extension power based on body weight (P=0.0343), and vertical jump performance (P=0.0485) were significantly higher in subjects with mitochondrial macrohaplogroup N than in those with macrohaplogroup M. However, peak oxygen uptake was similar between the 2 groups. When we analyzed the 12 haplogroups, all of the measured parameters were similar among them. In conclusion, mitochondrial macrohaplogroup N may be one of the determinant factors of anaerobic physical performance phenotype such as muscle power.

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalInternational journal of sports medicine
Volume33
Issue number5
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • haplogroup
  • leg extension power
  • mtDNA
  • physical fitness
  • polymorphism
  • vertical jump

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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