Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH): A review

Kazuyoshi Tsutsui, Takayoshi Ubuka, Hong Yin, Tomohiro Osugi, Kazuyoshi Ukena, George E. Bentley, Nick Ciccone, Kazuhiko Inoue, Vishwajit S. Chowdhury, Peter J. Sharp, John C. Wingfield

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Neuropeptide control of gonadotropin secretion at the level of the anterior pituitary gland is primarily through the stimulatory action of the hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH). However, a hypothalamic neuropeptide acting at the level of the pituitary to negatively regulate gonadotropin secretion has, until recently, remained unknown in any vertebrate. In 2000, we discovered a novel hypothalamic neuropeptide inhibiting gonadotropin release at the level of the pituitary in quail and termed it gonadotropin-inhibitory hormone (GnIH). A gonadotropin-inhibitory system is an intriguing concept and provides us with an unprecedented opportunity to study the regulation of avian reproduction from an entirely novel standpoint. To elucidate the mode of action of GnIH, we further identified the receptor for GnIH and characterized its expression and binding activity in quail. The identified GnIH receptor possessed seven transmembrane domains and specifically bound to GnIH in a concentration-dependent manner. The expression of GnIH receptor was found in the pituitary and several brain regions including the hypothalamus. These results suggest that GnIH acts directly on the pituitary via GnIH receptor to inhibit gonadotropin release. GnIH may also act on the hypothalamus to inhibit GnRH release. To understand the functional significance of GnIH in avian reproduction, we also investigated the mechanism that regulates GnIH expression. Interestingly, melatonin induced dose-dependently GnIH expression and melatonin receptor (Mel1c) was expressed in GnIH neurons. Thus melatonin appears to act directly on GnIH neurons via its receptor to induce GnIH expression. Based on these studies, GnIH is likely an important neuropeptide for the regulation of avian reproduction.

Original languageEnglish
Pages (from-to)801-806
Number of pages6
JournalJournal of Experimental Zoology Part A: Comparative Experimental Biology
Volume305
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1
Externally publishedYes

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gonadotropins
mechanism of action
hormones
neuropeptides
hormone receptors
melatonin
gonadotropin release
gonadotropin-releasing hormone
hypothalamus
quails
neurons
pituitary gonadotropins
secretion
receptors
anterior pituitary

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH) : A review. / Tsutsui, Kazuyoshi; Ubuka, Takayoshi; Yin, Hong; Osugi, Tomohiro; Ukena, Kazuyoshi; Bentley, George E.; Ciccone, Nick; Inoue, Kazuhiko; Chowdhury, Vishwajit S.; Sharp, Peter J.; Wingfield, John C.

In: Journal of Experimental Zoology Part A: Comparative Experimental Biology, Vol. 305, No. 9, 01.09.2006, p. 801-806.

Research output: Contribution to journalArticle

Tsutsui, K, Ubuka, T, Yin, H, Osugi, T, Ukena, K, Bentley, GE, Ciccone, N, Inoue, K, Chowdhury, VS, Sharp, PJ & Wingfield, JC 2006, 'Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH): A review', Journal of Experimental Zoology Part A: Comparative Experimental Biology, vol. 305, no. 9, pp. 801-806. https://doi.org/10.1002/jez.a.305
Tsutsui, Kazuyoshi ; Ubuka, Takayoshi ; Yin, Hong ; Osugi, Tomohiro ; Ukena, Kazuyoshi ; Bentley, George E. ; Ciccone, Nick ; Inoue, Kazuhiko ; Chowdhury, Vishwajit S. ; Sharp, Peter J. ; Wingfield, John C. / Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH) : A review. In: Journal of Experimental Zoology Part A: Comparative Experimental Biology. 2006 ; Vol. 305, No. 9. pp. 801-806.
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