Modeling of a propagation mechanism of infectious prion protein; a hexamer as the minimum infectious unit

Hironori K. Nakamura, Mitsunori Takano, Kazuo Kuwata

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    To construct a new model of the propagation mechanism of infectious scrapie-type prion protein (PrPSc), here we conducted a disruption simulation of a PrPSc nonamer using structure-based molecular dynamics simulation method based on a hypothetical PrPSc model structure. The simulation results showed that the nonamer disrupted in cooperative manners into monomers via two significant intermediate states: (1) a nonamer with a partially unfolded surface trimer and (2) a hexamer and three monomers. Dimers and trimers were rarely observed. Then, we propose a new PrPSc propagation mechanism where a hexamer plays an essential role as a minimum infectious unit.

    Original languageEnglish
    Pages (from-to)789-793
    Number of pages5
    JournalBiochemical and Biophysical Research Communications
    Volume361
    Issue number3
    DOIs
    Publication statusPublished - 2007 Sep 28

    Fingerprint

    Scrapie
    Molecular Dynamics Simulation
    Monomers
    PrPSc Proteins
    Model structures
    Dimers
    Molecular dynamics
    Computer simulation
    Prions
    Prion Proteins

    Keywords

    • Amyloid
    • Coarse-grained model
    • Go model
    • Molecular dynamics
    • Prion disease

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    Modeling of a propagation mechanism of infectious prion protein; a hexamer as the minimum infectious unit. / Nakamura, Hironori K.; Takano, Mitsunori; Kuwata, Kazuo.

    In: Biochemical and Biophysical Research Communications, Vol. 361, No. 3, 28.09.2007, p. 789-793.

    Research output: Contribution to journalArticle

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