Moderate physical exercise induces the oxidation of human blood protein thiols

Takayo Inayama, Jun Oka, Misato Kashiba, Makoto Saito, Mitsuru Higuchi, Keizo Umegaki, Yorihiro Yamamoto, Mitsuo Matsuda

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Exercise is known to induce the oxidation of blood low-molecular-weight (LMW) thiols such as reduced glutathione (GSH). We previously reported that full-marathon running induced a decrease in human plasma levels of protein-bound sulfhydryl groups (p-SHs). Moderate exercise, a 30-min running at the intensity of the individual ventilatory threshold, performed by untrained healthy females caused a significant decrease in erythrocyte levels of p-SHs (mostly hemoglobin cysteine residues) and LMW thiols, but their levels returned to each baseline by 2 h. No significant change in plasma LMW thiols was observed. However, plasma levels of p-SHs significantly decreased after running and remained unchanged after 24 h. These results suggest that moderate exercise causes the oxidation of blood thiols, especially protein-bound thiols.

Original languageEnglish
Pages (from-to)2039-2046
Number of pages8
JournalLife Sciences
Volume70
Issue number17
DOIs
Publication statusPublished - 2002 Mar 15
Externally publishedYes

Fingerprint

Sulfhydryl Compounds
Blood Proteins
Exercise
Oxidation
Running
Molecular Weight
Molecular weight
Proteins
Blood
Plasma (human)
Plasmas
Glutathione
Cysteine
Hemoglobins
Erythrocytes

Keywords

  • Erythrocytes
  • Glutathione
  • Moderate physical exercise
  • Oxidative stress
  • Sulfhydryl compounds

ASJC Scopus subject areas

  • Pharmacology

Cite this

Inayama, T., Oka, J., Kashiba, M., Saito, M., Higuchi, M., Umegaki, K., ... Matsuda, M. (2002). Moderate physical exercise induces the oxidation of human blood protein thiols. Life Sciences, 70(17), 2039-2046. https://doi.org/10.1016/S0024-3205(02)01490-X

Moderate physical exercise induces the oxidation of human blood protein thiols. / Inayama, Takayo; Oka, Jun; Kashiba, Misato; Saito, Makoto; Higuchi, Mitsuru; Umegaki, Keizo; Yamamoto, Yorihiro; Matsuda, Mitsuo.

In: Life Sciences, Vol. 70, No. 17, 15.03.2002, p. 2039-2046.

Research output: Contribution to journalArticle

Inayama, T, Oka, J, Kashiba, M, Saito, M, Higuchi, M, Umegaki, K, Yamamoto, Y & Matsuda, M 2002, 'Moderate physical exercise induces the oxidation of human blood protein thiols', Life Sciences, vol. 70, no. 17, pp. 2039-2046. https://doi.org/10.1016/S0024-3205(02)01490-X
Inayama T, Oka J, Kashiba M, Saito M, Higuchi M, Umegaki K et al. Moderate physical exercise induces the oxidation of human blood protein thiols. Life Sciences. 2002 Mar 15;70(17):2039-2046. https://doi.org/10.1016/S0024-3205(02)01490-X
Inayama, Takayo ; Oka, Jun ; Kashiba, Misato ; Saito, Makoto ; Higuchi, Mitsuru ; Umegaki, Keizo ; Yamamoto, Yorihiro ; Matsuda, Mitsuo. / Moderate physical exercise induces the oxidation of human blood protein thiols. In: Life Sciences. 2002 ; Vol. 70, No. 17. pp. 2039-2046.
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