Moderate physical exercise induces the oxidation of human blood protein thiols

Takayo Inayama, Jun Oka, Misato Kashiba, Makoto Saito, Mitsuru Higuchi, Keizo Umegaki, Yorihiro Yamamoto, Mitsuo Matsuda

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Exercise is known to induce the oxidation of blood low-molecular-weight (LMW) thiols such as reduced glutathione (GSH). We previously reported that full-marathon running induced a decrease in human plasma levels of protein-bound sulfhydryl groups (p-SHs). Moderate exercise, a 30-min running at the intensity of the individual ventilatory threshold, performed by untrained healthy females caused a significant decrease in erythrocyte levels of p-SHs (mostly hemoglobin cysteine residues) and LMW thiols, but their levels returned to each baseline by 2 h. No significant change in plasma LMW thiols was observed. However, plasma levels of p-SHs significantly decreased after running and remained unchanged after 24 h. These results suggest that moderate exercise causes the oxidation of blood thiols, especially protein-bound thiols.

Original languageEnglish
Pages (from-to)2039-2046
Number of pages8
JournalLife Sciences
Volume70
Issue number17
DOIs
Publication statusPublished - 2002 Mar 15
Externally publishedYes

Keywords

  • Erythrocytes
  • Glutathione
  • Moderate physical exercise
  • Oxidative stress
  • Sulfhydryl compounds

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Inayama, T., Oka, J., Kashiba, M., Saito, M., Higuchi, M., Umegaki, K., Yamamoto, Y., & Matsuda, M. (2002). Moderate physical exercise induces the oxidation of human blood protein thiols. Life Sciences, 70(17), 2039-2046. https://doi.org/10.1016/S0024-3205(02)01490-X