Modes of action of local hypothalamic and skin thermal stimulation on salivary secretion in rats

Kazuyuki Kanosue, T. Nakayama, H. Tanaka, M. Yanase, H. Yasuda

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In urethane or ketamine-anaesthetized rats, salivary secretion was observed when local brain sites or trunk skin were stimulated thermally or electrically. Salivary secretion was facilitated by bilateral local brain warming. Sensitive sites were restricted to the preoptic area and anterior hypothalamus, but in a region distinct from a previously reported sensitive for producing saliva-spreading behaviour. Unilateral warming of the preoptic area produced greater salivary secretion from the ipsilateral submandibular/sublingual salivary glands than from the contra-lateral glands. Electrical stimulation of the same sites elicited salivation only from the ipsilateral glands. Trunk skin, not including the scrotum, was unilaterally cooled when spontaneous salivary secretion was observed in a hot environment. Salivary secretion from both sides was equally suppressed in response to the unilateral skin cooling. We conclude that efferent signals from the anterior part of the hypothalamus project dominantly to the ipsilateral salivary gland for thermally induced salivary secretion. Thermal signals from the skin of either side of the trunk, on the other hand, appear to be integrated and to affect salivary secretion bilaterally.

Original languageEnglish
Pages (from-to)459-471
Number of pages13
JournalJournal of Physiology
Volume424
Publication statusPublished - 1990
Externally publishedYes

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Hot Temperature
Anterior Hypothalamus
Skin
Preoptic Area
Salivary Glands
Sublingual Gland
Salivation
Scrotum
Urethane
Brain
Ketamine
Saliva
Electric Stimulation

ASJC Scopus subject areas

  • Physiology

Cite this

Modes of action of local hypothalamic and skin thermal stimulation on salivary secretion in rats. / Kanosue, Kazuyuki; Nakayama, T.; Tanaka, H.; Yanase, M.; Yasuda, H.

In: Journal of Physiology, Vol. 424, 1990, p. 459-471.

Research output: Contribution to journalArticle

Kanosue, Kazuyuki ; Nakayama, T. ; Tanaka, H. ; Yanase, M. ; Yasuda, H. / Modes of action of local hypothalamic and skin thermal stimulation on salivary secretion in rats. In: Journal of Physiology. 1990 ; Vol. 424. pp. 459-471.
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