Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone

Takayoshi Ubuka, You Lee Son, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that was isolated from the brains of Japanese quail in 2000, which inhibited luteinizing hormone release from the anterior pituitary gland. Here, we summarize the following fifteen years of researches that investigated on the mechanism of GnIH actions at molecular, cellular, morphological, physiological, and behavioral levels. The unique molecular structure of GnIH peptide is in its LPXRFamide (X = L or Q) motif at its C-terminal. The primary receptor for GnIH is GPR147. The cell signaling pathway triggered by GnIH is initiated by inhibiting adenylate cyclase and decreasing cAMP production in the target cell. GnIH neurons regulate not only gonadotropin synthesis and release in the pituitary, but also regulate various neurons in the brain, such as GnRH1, GnRH2, dopamine, POMC, NPY, orexin, MCH, CRH, oxytocin, and kisspeptin neurons. GnIH and GPR147 are also expressed in gonads and they may regulate steroidogenesis and germ cell maturation in an autocrine/paracrine manner. GnIH regulates reproductive development and activity. In female mammals, GnIH may regulate estrous or menstrual cycle. GnIH is also involved in the regulation of seasonal reproduction, but GnIH may finely tune reproductive activities in the breeding seasons. It is involved in stress responses not only in the brain but also in gonads. GnIH may inhibit male socio-sexual behavior by stimulating the activity of cytochrome P450 aromatase in the brain and stimulates feeding behavior by modulating the activities of hypothalamic and central amygdala neurons.

    Original languageEnglish
    Pages (from-to)27-50
    Number of pages24
    JournalGeneral and Comparative Endocrinology
    Volume227
    DOIs
    Publication statusPublished - 2016 Feb 1

    Fingerprint

    gonadotropins
    Gonadotropins
    hormones
    Hormones
    neurons
    brain
    Neurons
    Brain
    Gonads
    gonads
    Gonadotropin Receptors
    Kisspeptins
    Coturnix
    peptide hormones
    Pro-Opiomelanocortin
    amygdala
    menstrual cycle
    anterior pituitary
    steroidogenesis
    adenylate cyclase

    Keywords

    • Feeding behavior
    • Gonadotropin-inhibitory hormone (GnIH)
    • Gonadotropins
    • RFamide-related peptide (RFRP)
    • Socio-sexual behavior
    • Stress

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone. / Ubuka, Takayoshi; Son, You Lee; Tsutsui, Kazuyoshi.

    In: General and Comparative Endocrinology, Vol. 227, 01.02.2016, p. 27-50.

    Research output: Contribution to journalArticle

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