TY - JOUR
T1 - Molecular design and morphology of peptide nanotubes
T2 - Towards the novel drug delivery materials
AU - Okamoto, H.
AU - Takeda, K.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2005
Y1 - 2005
N2 - Peptide nanotubes (PNTs) are an artificial protein, being formed by the self-assembly of peptide nanorings (PNRs) consisting of alternate sequences of D- and L-amino acid residues (D,L-peptide). Because they have hollow cores and internal cavities, they are expected to be the novel drug delivery system in the future. Here, in order to give the guiding principle of the molecular design, possible molecular conformations of the peptide nanorings and nanotubes were theoretically investigated and the electronic structures were also studied by ab initio calculations. The syntheses and atomic force microscopy were further performed and the morphology of the peptide nanotubes was investigated experimentally.
AB - Peptide nanotubes (PNTs) are an artificial protein, being formed by the self-assembly of peptide nanorings (PNRs) consisting of alternate sequences of D- and L-amino acid residues (D,L-peptide). Because they have hollow cores and internal cavities, they are expected to be the novel drug delivery system in the future. Here, in order to give the guiding principle of the molecular design, possible molecular conformations of the peptide nanorings and nanotubes were theoretically investigated and the electronic structures were also studied by ab initio calculations. The syntheses and atomic force microscopy were further performed and the morphology of the peptide nanotubes was investigated experimentally.
KW - Ab initio calculation
KW - Atomic force
KW - Electronic structures
KW - Microspectroscopy
KW - Molecular structures
KW - Peptide nanotubes
UR - http://www.scopus.com/inward/record.url?scp=13444271643&partnerID=8YFLogxK
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U2 - 10.1016/s1773-2247(05)50012-1
DO - 10.1016/s1773-2247(05)50012-1
M3 - Article
AN - SCOPUS:13444271643
VL - 15
SP - 97
EP - 107
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
SN - 1157-1489
IS - 1
ER -