Molecular design and morphology of peptide nanotubes: Towards the novel drug delivery materials

H. Okamoto, Kyozaburo Takeda

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    4 Citations (Scopus)

    Abstract

    Peptide nanotubes (PNTs) are an artificial protein, being formed by the self-assembly of peptide nanorings (PNRs) consisting of alternate sequences of D- and L-amino acid residues (D,L-peptide). Because they have hollow cores and internal cavities, they are expected to be the novel drug delivery system in the future. Here, in order to give the guiding principle of the molecular design, possible molecular conformations of the peptide nanorings and nanotubes were theoretically investigated and the electronic structures were also studied by ab initio calculations. The syntheses and atomic force microscopy were further performed and the morphology of the peptide nanotubes was investigated experimentally.

    Original languageEnglish
    Pages (from-to)97-107
    Number of pages11
    JournalJournal of Drug Delivery Science and Technology
    Volume15
    Issue number1
    Publication statusPublished - 2005 Jan

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    Keywords

    • Ab initio calculation
    • Atomic force
    • Electronic structures
    • Microspectroscopy
    • Molecular structures
    • Peptide nanotubes

    ASJC Scopus subject areas

    • Pharmaceutical Science

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