Molecular engineering of supramolecular scaffold coatings that can reduce static platelet adhesion

Aryavarta M S Kumar, Sona Sivakova, Justin D. Fox, Jennifer E. Green, Roger E. Marchant, Stuart J. Rowan

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Novel supramolecular coatings that make use of low-molecular weight ditopic monomers with guanine end groups are studied using fluid tapping AFM. These molecules assemble on highly oriented pyrolytic graphite (HOPG) from aqueous solutions to form nanosized banding structures whose sizes can be systematically tuned at the nanoscale by tailoring the molecular structure of the monomers. The nature of the self-assembly in these systems has been studied through a combination of the self-assembly of structural derivatives and molecular modeling. Furthermore, we introduce the concept of using these molecular assemblies as scaffolds to organize functional groups on the surface. As a first demonstration of this concept, scaffold monomers that contain a monomethyl triethyleneglycol branch were used to organize these "functional" units on a HOPG surface. These supramolecular grafted assemblies have been shown to be stable at biologically relevant temperatures and even have the ability to significantly reduce static platelet adhesion.

Original languageEnglish
Pages (from-to)1466-1476
Number of pages11
JournalJournal of the American Chemical Society
Volume130
Issue number4
DOIs
Publication statusPublished - 2008 Jan 30
Externally publishedYes

Fingerprint

Graphite
Platelets
Scaffolds
Blood Platelets
Adhesion
Monomers
Coatings
Self assembly
Guanine
Molecular Structure
Molecular modeling
Molecular Weight
Functional groups
Molecular structure
Temperature
Demonstrations
Molecular weight
Derivatives
Molecules
Fluids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Kumar, A. M. S., Sivakova, S., Fox, J. D., Green, J. E., Marchant, R. E., & Rowan, S. J. (2008). Molecular engineering of supramolecular scaffold coatings that can reduce static platelet adhesion. Journal of the American Chemical Society, 130(4), 1466-1476. https://doi.org/10.1021/ja0775927

Molecular engineering of supramolecular scaffold coatings that can reduce static platelet adhesion. / Kumar, Aryavarta M S; Sivakova, Sona; Fox, Justin D.; Green, Jennifer E.; Marchant, Roger E.; Rowan, Stuart J.

In: Journal of the American Chemical Society, Vol. 130, No. 4, 30.01.2008, p. 1466-1476.

Research output: Contribution to journalArticle

Kumar, AMS, Sivakova, S, Fox, JD, Green, JE, Marchant, RE & Rowan, SJ 2008, 'Molecular engineering of supramolecular scaffold coatings that can reduce static platelet adhesion', Journal of the American Chemical Society, vol. 130, no. 4, pp. 1466-1476. https://doi.org/10.1021/ja0775927
Kumar, Aryavarta M S ; Sivakova, Sona ; Fox, Justin D. ; Green, Jennifer E. ; Marchant, Roger E. ; Rowan, Stuart J. / Molecular engineering of supramolecular scaffold coatings that can reduce static platelet adhesion. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 4. pp. 1466-1476.
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