Monitoring cellular events in living mast cells stimulated with an extremely small amount of fluid on a microchip

Tatsuya Munaka, Hirohisa Abe, Masaki Kanai, Takashi Sakamoto, Hiroaki Nakanishi, Tetsuji Yamaoka, Shuichi Shoji, Akira Murakami

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We successfully developed a measurement system for real-time analysis of cellular function using a newly designed microchip. This microchip was equipped with a micro cell incubation chamber (240 nl) and was stimulated by a very small amount of stimuli (as small as 24 nl). Using the microchip system, cultivation of mast cells was successfully carried out. Monitoring of the cellular events after stimulation with an extremely small amount of fluid on a microchip was performed. This system could be applicable for various types of cellular analysis including real-time monitoring of cellular response by stimulation.

Original languageEnglish
Pages (from-to)L634-L637
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume45
Issue number24-28
DOIs
Publication statusPublished - 2006 Jun 16

Keywords

  • Cell stimulation
  • Cellular analysis
  • Real-time monitoring
  • μTAS

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

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