Monoamines, insulin and the roles they play in associative learning in pond snails

Yuki Totani, Hitoshi Aonuma, Akira Oike, Takayuki Watanabe, Dai Hatakeyama, Manabu Sakakibara, Ken Lukowiak, Etsuro Ito

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Molluscan gastropods have long been used for studying the cellular and molecular mechanisms underlying learning and memory. One such gastropod, the pond snail Lymnaea stagnalis, exhibits long-term memory (LTM) following both classical and operant conditioning. Using Lymnaea, we have successfully elucidated cellular mechanisms of learning and memory utilizing an aversive classical conditioning procedure, conditioned taste aversion (CTA). Here, we present the behavioral changes following CTA training and show that the memory score depends on the duration of food deprivation. Then, we describe the relationship between the memory scores and the monoamine contents of the central nervous system (CNS). A comparison of learning capability in two different strains of Lymnaea, as well as the filial 1 (F 1 ) cross from the two strains, presents how the memory scores are correlated in these populations with monoamine contents. Overall, when the memory scores are better, the monoamine contents of the CNS are lower. We also found that as the insulin content of the CNS decreases so does the monoamine contents which are correlated with higher memory scores. The present review deepens the relationship between monoamine and insulin contents with the memory score.

Original languageEnglish
Article number65
JournalFrontiers in Behavioral Neuroscience
Volume13
DOIs
Publication statusPublished - 2019 Apr 2

Fingerprint

Snails
Learning
Insulin
Lymnaea
Gastropoda
Classical Conditioning
Central Nervous System
Operant Conditioning
Food Deprivation
Long-Term Memory
Population

Keywords

  • 5-HT
  • Conditioned taste aversion
  • Dopamine
  • Insulin
  • Lymnaea
  • Octopamine

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Monoamines, insulin and the roles they play in associative learning in pond snails. / Totani, Yuki; Aonuma, Hitoshi; Oike, Akira; Watanabe, Takayuki; Hatakeyama, Dai; Sakakibara, Manabu; Lukowiak, Ken; Ito, Etsuro.

In: Frontiers in Behavioral Neuroscience, Vol. 13, 65, 02.04.2019.

Research output: Contribution to journalReview article

Totani, Yuki ; Aonuma, Hitoshi ; Oike, Akira ; Watanabe, Takayuki ; Hatakeyama, Dai ; Sakakibara, Manabu ; Lukowiak, Ken ; Ito, Etsuro. / Monoamines, insulin and the roles they play in associative learning in pond snails. In: Frontiers in Behavioral Neuroscience. 2019 ; Vol. 13.
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