Abstract
Background: Among 15 monozygotic twin pairs described in the literature, only four pairs were considered to be concordant. There is no detailed report of HLA-DRB1*1501/DQB1*0602 positive monozygotic twins concordant for narcolepsy, with marked difference in the age of onset. Methods: We compared a pair of female narcoleptic twins clinically. Results: Diagnosis of narcolepsy and monozygosity of the twins were confirmed. The second-born twin demonstrated a typical course of narcolepsy, whereas the first-born twin had a very late onset of recurrent daytime sleep episodes at age 45 and cataplexy at age 50 years, which was apparently triggered by chronic emotional stresses and sleep insufficiency. Conclusions: The atypical course of narcolepsy in the first-born twin supports the multifactorial model for the development of narcolepsy. It was noted that cataplexy was preceded by sustained polyphasic sleep conditions. Our observation implies that the unaffected co-twins in discordant pairs could develop narcolepsy in stressful situations later in their lives.
| Original language | English |
|---|---|
| Pages (from-to) | 943-947 |
| Number of pages | 5 |
| Journal | Biological Psychiatry |
| Volume | 49 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2001 Jun 1 |
| Externally published | Yes |
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Keywords
- Environmental factors
- HLA
- Incomplete concordance
- Monozygotic twins
- Narcolepsy
- Polysomnogram
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Monozygotic twins incompletely concordant for narcolepsy. / Honda, Makoto; Honda, Yutaka; Uchida, Sunao; Miyazaki, Shin Ichi; Tokunaga, Katsushi.
In: Biological Psychiatry, Vol. 49, No. 11, 01.06.2001, p. 943-947.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monozygotic twins incompletely concordant for narcolepsy
AU - Honda, Makoto
AU - Honda, Yutaka
AU - Uchida, Sunao
AU - Miyazaki, Shin Ichi
AU - Tokunaga, Katsushi
PY - 2001/6/1
Y1 - 2001/6/1
N2 - Background: Among 15 monozygotic twin pairs described in the literature, only four pairs were considered to be concordant. There is no detailed report of HLA-DRB1*1501/DQB1*0602 positive monozygotic twins concordant for narcolepsy, with marked difference in the age of onset. Methods: We compared a pair of female narcoleptic twins clinically. Results: Diagnosis of narcolepsy and monozygosity of the twins were confirmed. The second-born twin demonstrated a typical course of narcolepsy, whereas the first-born twin had a very late onset of recurrent daytime sleep episodes at age 45 and cataplexy at age 50 years, which was apparently triggered by chronic emotional stresses and sleep insufficiency. Conclusions: The atypical course of narcolepsy in the first-born twin supports the multifactorial model for the development of narcolepsy. It was noted that cataplexy was preceded by sustained polyphasic sleep conditions. Our observation implies that the unaffected co-twins in discordant pairs could develop narcolepsy in stressful situations later in their lives.
AB - Background: Among 15 monozygotic twin pairs described in the literature, only four pairs were considered to be concordant. There is no detailed report of HLA-DRB1*1501/DQB1*0602 positive monozygotic twins concordant for narcolepsy, with marked difference in the age of onset. Methods: We compared a pair of female narcoleptic twins clinically. Results: Diagnosis of narcolepsy and monozygosity of the twins were confirmed. The second-born twin demonstrated a typical course of narcolepsy, whereas the first-born twin had a very late onset of recurrent daytime sleep episodes at age 45 and cataplexy at age 50 years, which was apparently triggered by chronic emotional stresses and sleep insufficiency. Conclusions: The atypical course of narcolepsy in the first-born twin supports the multifactorial model for the development of narcolepsy. It was noted that cataplexy was preceded by sustained polyphasic sleep conditions. Our observation implies that the unaffected co-twins in discordant pairs could develop narcolepsy in stressful situations later in their lives.
KW - Environmental factors
KW - HLA
KW - Incomplete concordance
KW - Monozygotic twins
KW - Narcolepsy
KW - Polysomnogram
UR - http://www.scopus.com/inward/record.url?scp=0035370714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035370714&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(01)01090-3
DO - 10.1016/S0006-3223(01)01090-3
M3 - Article
C2 - 11377412
AN - SCOPUS:0035370714
VL - 49
SP - 943
EP - 947
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 11
ER -