Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells

Tetsuya Tsuji, Shinji Takeoka, Yosuke Okamura, Ryo Sudo, Yasuo Ikeda, Kazuo Tanishita

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s-1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.

    Original languageEnglish
    Pages (from-to)29-34
    Number of pages6
    JournalJournal of Biorheology
    Volume23
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Albumins
    Blood
    Cells
    Glycoproteins
    High speed cameras
    Platelets
    Shear deformation
    Adhesion
    Ligands
    von Willebrand Factor
    Platelet Glycoprotein GPIb-IX Complex

    Keywords

    • Lateral motion
    • Platelet substitute
    • Polymerized albumin particles
    • Von Willebrand factor

    ASJC Scopus subject areas

    • Mechanics of Materials
    • Materials Science(all)
    • Mechanical Engineering

    Cite this

    Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells. / Tsuji, Tetsuya; Takeoka, Shinji; Okamura, Yosuke; Sudo, Ryo; Ikeda, Yasuo; Tanishita, Kazuo.

    In: Journal of Biorheology, Vol. 23, No. 1, 2009, p. 29-34.

    Research output: Contribution to journalArticle

    Tsuji, Tetsuya ; Takeoka, Shinji ; Okamura, Yosuke ; Sudo, Ryo ; Ikeda, Yasuo ; Tanishita, Kazuo. / Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells. In: Journal of Biorheology. 2009 ; Vol. 23, No. 1. pp. 29-34.
    @article{9b5e97ef0abf4455acf1760fb130ed40,
    title = "Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells",
    abstract = "Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s-1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.",
    keywords = "Lateral motion, Platelet substitute, Polymerized albumin particles, Von Willebrand factor",
    author = "Tetsuya Tsuji and Shinji Takeoka and Yosuke Okamura and Ryo Sudo and Yasuo Ikeda and Kazuo Tanishita",
    year = "2009",
    doi = "10.1007/s12573-009-0005-0",
    language = "English",
    volume = "23",
    pages = "29--34",
    journal = "Journal of Biorheology",
    issn = "1867-0466",
    publisher = "Springer Japan",
    number = "1",

    }

    TY - JOUR

    T1 - Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells

    AU - Tsuji, Tetsuya

    AU - Takeoka, Shinji

    AU - Okamura, Yosuke

    AU - Sudo, Ryo

    AU - Ikeda, Yasuo

    AU - Tanishita, Kazuo

    PY - 2009

    Y1 - 2009

    N2 - Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s-1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.

    AB - Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s-1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.

    KW - Lateral motion

    KW - Platelet substitute

    KW - Polymerized albumin particles

    KW - Von Willebrand factor

    UR - http://www.scopus.com/inward/record.url?scp=78651525381&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=78651525381&partnerID=8YFLogxK

    U2 - 10.1007/s12573-009-0005-0

    DO - 10.1007/s12573-009-0005-0

    M3 - Article

    VL - 23

    SP - 29

    EP - 34

    JO - Journal of Biorheology

    JF - Journal of Biorheology

    SN - 1867-0466

    IS - 1

    ER -