Mucosal immune function comparison between amenorrheic and eumenorrheic distance runners

Kazuhiro Shimizu, Natsumi Suzuki, Mariko Nakamura, Katsuji Aizawa, Tomoko Imai, Satomi Suzuki, Nobuhiko Eda, Yukichi Hanaoka, Kikuko Nakao, Naoto Suzuki, Noboru Mesaki, Ichiro Kono, Takao Akama

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study examined the effects of amenorrhea on mucosal immune function and susceptibility to upper respiratory tract infection (URTI) in elite female distance runners. Based on their menstrual cycles during the prior year, 21 elite, collegiate, female distance runners were designated as eumenorrheic runners (ERs; n = 8; 19.9 ± 0.8 years) or amenorrheic runners (ARs; n = 13; 20.0 ± 0.3 years). Resting saliva and blood samples were collected in the morning. The secretory immunoglobulin A (SIgA) concentration was measured using enzyme-linked immunosorbent assay. The SIgA secretion rate was calculated. Serum 17b-estradiol concentrations and serum progesterone concentrations were measured using radioimmunoassay. Subjects reported the appearance of URTI symptoms (sore throat, headache, runny nose, coughing, or fever), if any, during the prior month. The serum estradiol concentration and salivary SIgA secretion rate were significantly lower for ARs than for ERs (p < 0.05). Serum progesterone concentration was not significantly different between groups. Higher frequencies of headache, runny nose, coughing, and fever were observed in ARs than in ERs. Results show that athletic amenorrhea with low estrogen might accelerate downregulation of mucosal immune function in athletes and enhance susceptibility to infection.

Original languageEnglish
Pages (from-to)1402-1406
Number of pages5
JournalJournal of Strength and Conditioning Research
Volume26
Issue number5
DOIs
Publication statusPublished - 2012 May

Fingerprint

Secretory Immunoglobulin A
Amenorrhea
Serum
Nose
Respiratory Tract Infections
Progesterone
Headache
Estradiol
Fever
Pharyngitis
Menstrual Cycle
Saliva
Athletes
Radioimmunoassay
Sports
Estrogens
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Infection

Keywords

  • Athletic amenorrhea
  • Female hormone
  • Infection
  • Secretory immunoglobulin A

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Mucosal immune function comparison between amenorrheic and eumenorrheic distance runners. / Shimizu, Kazuhiro; Suzuki, Natsumi; Nakamura, Mariko; Aizawa, Katsuji; Imai, Tomoko; Suzuki, Satomi; Eda, Nobuhiko; Hanaoka, Yukichi; Nakao, Kikuko; Suzuki, Naoto; Mesaki, Noboru; Kono, Ichiro; Akama, Takao.

In: Journal of Strength and Conditioning Research, Vol. 26, No. 5, 05.2012, p. 1402-1406.

Research output: Contribution to journalArticle

Shimizu, K, Suzuki, N, Nakamura, M, Aizawa, K, Imai, T, Suzuki, S, Eda, N, Hanaoka, Y, Nakao, K, Suzuki, N, Mesaki, N, Kono, I & Akama, T 2012, 'Mucosal immune function comparison between amenorrheic and eumenorrheic distance runners', Journal of Strength and Conditioning Research, vol. 26, no. 5, pp. 1402-1406. https://doi.org/10.1519/JSC.0b013e31822e7a6c
Shimizu, Kazuhiro ; Suzuki, Natsumi ; Nakamura, Mariko ; Aizawa, Katsuji ; Imai, Tomoko ; Suzuki, Satomi ; Eda, Nobuhiko ; Hanaoka, Yukichi ; Nakao, Kikuko ; Suzuki, Naoto ; Mesaki, Noboru ; Kono, Ichiro ; Akama, Takao. / Mucosal immune function comparison between amenorrheic and eumenorrheic distance runners. In: Journal of Strength and Conditioning Research. 2012 ; Vol. 26, No. 5. pp. 1402-1406.
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