Multinuclear Pd/Zn complex-catalyzed asymmetric alkylative ring-opening reaction of oxabicyclic alkenes

Kohei Endo, Keisuke Tanaka, Mika Ogawa, Takanori Shibata

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    A multinuclear palladium catalyst can be used to realize the efficient catalytic asymmetric alkylative ring-opening reaction of oxabicyclic alkenes using dimethylzinc. The use of (R)-BINOL-PHOS bearing bisphosphine and diol moieties is essential for achieving excellent catalytic performance; the corresponding monophosphine and hydroxy-protected derivatives showed lower catalytic activities and/or enantioselectivities. The generation of Pd/Zn-multinuclear complexes is a key feature of the present catalysis.(Figure Presented)

    Original languageEnglish
    Pages (from-to)868-871
    Number of pages4
    JournalOrganic Letters
    Volume13
    Issue number5
    DOIs
    Publication statusPublished - 2011 Mar 4

    Fingerprint

    Bearings (structural)
    Enantioselectivity
    Palladium
    Alkenes
    Catalysis
    alkenes
    catalysis
    catalytic activity
    palladium
    Catalyst activity
    Derivatives
    catalysts
    Catalysts
    rings
    dimethylzinc
    naphthol BINOL

    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

    Cite this

    Multinuclear Pd/Zn complex-catalyzed asymmetric alkylative ring-opening reaction of oxabicyclic alkenes. / Endo, Kohei; Tanaka, Keisuke; Ogawa, Mika; Shibata, Takanori.

    In: Organic Letters, Vol. 13, No. 5, 04.03.2011, p. 868-871.

    Research output: Contribution to journalArticle

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