Multinuclear Pd/Zn complex-catalyzed asymmetric alkylative ring-opening reaction of oxabicyclic alkenes

Kohei Endo, Keisuke Tanaka, Mika Ogawa, Takanori Shibata

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Abstract

A multinuclear palladium catalyst can be used to realize the efficient catalytic asymmetric alkylative ring-opening reaction of oxabicyclic alkenes using dimethylzinc. The use of (R)-BINOL-PHOS bearing bisphosphine and diol moieties is essential for achieving excellent catalytic performance; the corresponding monophosphine and hydroxy-protected derivatives showed lower catalytic activities and/or enantioselectivities. The generation of Pd/Zn-multinuclear complexes is a key feature of the present catalysis.(Figure Presented)

Original languageEnglish
Pages (from-to)868-871
Number of pages4
JournalOrganic Letters
Volume13
Issue number5
DOIs
Publication statusPublished - 2011 Mar 4

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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