Multiple flow switch using stepwise sheath flow

Masaki Kanai, Shin Ichiro Otsuka, Hiroaki Nakanishi, Shuichi Shoji

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    In this paper we present a concentration-conservative flow switch using a sheath flow. A novel concept of stepwise flow was proposed to prevent the sample dilution during flow switching. Computational fluid dynamics (CFD) simulations revealed that the stepwise flow suppressed a back flow of the sample reagent that caused the sample dilution. Based on the CFD simulation results, the prototype devices of the flow switch utilizing the stepwise flow were designed. Using fabricated devices, reduction of the sample dilution by the stepwise flow was confirmed. In order to reduce the switching time, pneumatic microvalves were integrated with the flow switch. Its characteristic of the switching time was evaluated experimentally. The switching time was about 130 ms, which was reduced to less than half compared to the case of using off-chip valves. In the case that the sample flow rate is 1 μL/min, it is expected that the flow switch will achieve fluid sampling with the accuracy of the order of nanoliters.

    Original languageEnglish
    Pages (from-to)3849-3854
    Number of pages6
    JournalJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
    Volume43
    Issue number6 B
    DOIs
    Publication statusPublished - 2004 Jun

    Fingerprint

    sheaths
    switches
    Switches
    Dilution
    Computational fluid dynamics
    Computer simulation
    dilution
    Pneumatics
    computational fluid dynamics
    Flow rate
    Sampling
    Fluids
    pneumatics
    reagents
    simulation
    flow velocity
    sampling
    chips
    prototypes
    fluids

    Keywords

    • μTAS
    • CFD simulation
    • Flow switch
    • Sample dilution
    • Sheath flow
    • Stepwise flow

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

    Cite this

    Multiple flow switch using stepwise sheath flow. / Kanai, Masaki; Otsuka, Shin Ichiro; Nakanishi, Hiroaki; Shoji, Shuichi.

    In: Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, Vol. 43, No. 6 B, 06.2004, p. 3849-3854.

    Research output: Contribution to journalArticle

    Kanai, Masaki ; Otsuka, Shin Ichiro ; Nakanishi, Hiroaki ; Shoji, Shuichi. / Multiple flow switch using stepwise sheath flow. In: Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers. 2004 ; Vol. 43, No. 6 B. pp. 3849-3854.
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