Multiple subtypes of serotonin receptors in the feeding circuit of a pond snail

Ryo Kawai, Suguru Kobayashi, Yutaka Fujito, Etsuro Ito

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In the central nervous system of the pond snail Lymnaea stagnalis, serotonergic transmission plays an important role in controlling feeding behavior. Recent electrophysiological studies have claimed that only metabotropic serotonin (5-HT 2) receptors, and not ionotropic (5-HT 3) receptors, are used in synapses between serotonergic neurons (the cerebral giant cells, CGCs) and the follower buccal motoneurons (the B1 cells). However, these data are inconsistent with previous results. In the present study, we therefore reexamined the serotonin receptors to identify the receptor subtypes functioning in the synapses between the CGCs and the B1 cells by recording the compound excitatory postsynaptic potential (EPSP) of the B1 cells evoked by a train of stimulation to the CGC in the presence of antagonists: cinanserin for 5-HT 2 and/or MDL72222 for 5-HT 3. The compound EPSP amplitude was partially suppressed by the application of these antagonists. The rise time of the compound EPSP was longer in the presence of MDL72222 than in that of cinanserin. These results suggest that these two subtypes of serotonin receptors are involved in the CGC-B1 synapses, and that these receptors contribute to compound EPSP. That is, the fast component of compound EPSP is mediated by 5-HT 3-like receptors, and the slow component is generated via 5-HT 2-like receptors.

Original languageEnglish
Pages (from-to)517-525
Number of pages9
JournalZoological Science
Volume28
Issue number7
DOIs
Publication statusPublished - 2011 Jul
Externally publishedYes

Fingerprint

serotonin
snails
giant cells
receptors
synapse
antagonists
Lymnaea stagnalis
cells
motor neurons
serotonin receptors
feeding behavior
central nervous system
neurons

Keywords

  • feeding
  • Lymnaea
  • mollusc
  • receptor
  • serotonin
  • synaptic transmission

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Multiple subtypes of serotonin receptors in the feeding circuit of a pond snail. / Kawai, Ryo; Kobayashi, Suguru; Fujito, Yutaka; Ito, Etsuro.

In: Zoological Science, Vol. 28, No. 7, 07.2011, p. 517-525.

Research output: Contribution to journalArticle

Kawai, Ryo ; Kobayashi, Suguru ; Fujito, Yutaka ; Ito, Etsuro. / Multiple subtypes of serotonin receptors in the feeding circuit of a pond snail. In: Zoological Science. 2011 ; Vol. 28, No. 7. pp. 517-525.
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