Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation

Satoshi Hayakawa, Tomoyuki Fujikawa, Hideoki Fukuoka, Fumihisa Chisima, Miki Karasaki-Suzuki, Emika Ohkoshi, Hiroyuki Ohi, Tom Kiyoshi Fujii, Meijin Tochigi, Kazuo Satoh, Takako Shimizu, Susumu Nishinarita, Norimichi Nemoto, Isamu Sakurai

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Abstract

It has been proposed that immune responses in mammalian normal pregnancy are Th2-like, thereby protecting the fetus and placenta from being rejected. Administration of exogenous Th1 cytokines into pregnant mice is reported to induce feto-placental resorption. However, the effects of exogenous Th2 cytokines and Th2 directed responses in pregnant animals have not been well studied. In this study, we examined IL-4 and IL-12, which play decisive roles in the development of Th2 and Th1 responses, respectively, in the induction of fetal resorption and development of experimental pre-eclampsia. Transfer of either IL-4 and/or IL-12 stimulated splenocytes from BALB/C virgin female mice into BALB/C pregnant mice mated with either C57BL/6 or BALB/C male mice resulted in fetal resorption and glomerular nephritis associated with hypertension and proteinuria. In mice treated with IL-12 stimulated splenocytes, fatty liver degeneration associated with bile retention was observed. These results indicate that both excessive Th1 and Th2 activation contribute to the development of fetal resorption and pre-eclampsia, but that Th1 is critical to the development of liver degeneration. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)121-138
Number of pages18
JournalJournal of Reproductive Immunology
Volume47
Issue number2
DOIs
Publication statusPublished - 2000 Jul
Externally publishedYes

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Keywords

  • Fetal resorption
  • Pre-eclampsia
  • Th1/Th2

ASJC Scopus subject areas

  • Immunology
  • Reproductive Medicine

Cite this

Hayakawa, S., Fujikawa, T., Fukuoka, H., Chisima, F., Karasaki-Suzuki, M., Ohkoshi, E., Ohi, H., Kiyoshi Fujii, T., Tochigi, M., Satoh, K., Shimizu, T., Nishinarita, S., Nemoto, N., & Sakurai, I. (2000). Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation. Journal of Reproductive Immunology, 47(2), 121-138. https://doi.org/10.1016/S0165-0378(00)00053-X