Muscle plasticity and β 2-adrenergic receptors: Adaptive responses of β 2-adrenergic receptor expression to muscle hypertrophy and atrophy

Shogo Sato, Ken Shirato, Kaoru Tachiyashiki, Kazuhiko Imaizumi

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    28 Citations (Scopus)

    Abstract

    We discuss the functional roles of β 2 -adrenergic receptors in skeletal muscle hypertrophy and atrophy as well as the adaptive responses of 2 -adrenergic receptor expression to anabolic and catabolic conditions. β 2-Adrenergic receptor stimulation using anabolic drugs increases muscle mass by promoting muscle protein synthesis and/or attenuating protein degradation. These effects are prevented by the downregulation of the receptor. Endurance training improves oxidative performance partly by increasing β 2-adrenergic receptor density in exercise-recruited slow-twitch muscles. However, excessive stimulation of β 2- adrenergic receptors negates their beneficial effects. Although the preventive effects of β 2-adrenergic receptor stimulation on atrophy induced by muscle disuse and catabolic hormones or drugs are observed, these catabolic conditions decrease β 2-adrenergic receptor expression in slow-twitch muscles. These findings present evidence against the use of β 2-adrenergic agonists in therapy for muscle wasting and weakness. Thus, β 2-adrenergic receptors in the skeletal muscles play an important physiological role in the regulation of protein and energy balance.

    Original languageEnglish
    Article number729598
    JournalJournal of Biomedicine and Biotechnology
    Volume2011
    DOIs
    Publication statusPublished - 2011

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    ASJC Scopus subject areas

    • Biotechnology
    • Molecular Medicine
    • Genetics
    • Molecular Biology
    • Health, Toxicology and Mutagenesis
    • Medicine(all)

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