Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies

Haruki Momma, Ryoko Kawakami, Takanori Honda, Susumu S. Sawada

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

OBJECTIVE: To quantify the associations between muscle-strengthening activities and the risk of non-communicable diseases and mortality in adults independent of aerobic activities. DESIGN: Systematic review and meta-analysis of prospective cohort studies. DATA SOURCES: MEDLINE and Embase were searched from inception to June 2021 and the reference lists of all related articles were reviewed. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Prospective cohort studies that examined the association between muscle-strengthening activities and health outcomes in adults aged ≥18 years without severe health conditions. RESULTS: Sixteen studies met the eligibility criteria. Muscle-strengthening activities were associated with a 10-17% lower risk of all-cause mortality, cardiovascular disease (CVD), total cancer, diabetes and lung cancer. No association was found between muscle-strengthening activities and the risk of some site-specific cancers (colon, kidney, bladder and pancreatic cancers). J-shaped associations with the maximum risk reduction (approximately 10-20%) at approximately 30-60 min/week of muscle-strengthening activities were found for all-cause mortality, CVD and total cancer, whereas an L-shaped association showing a large risk reduction at up to 60 min/week of muscle-strengthening activities was observed for diabetes. Combined muscle-strengthening and aerobic activities (versus none) were associated with a lower risk of all-cause, CVD and total cancer mortality. CONCLUSION: Muscle-strengthening activities were inversely associated with the risk of all-cause mortality and major non-communicable diseases including CVD, total cancer, diabetes and lung cancer; however, the influence of a higher volume of muscle-strengthening activities on all-cause mortality, CVD and total cancer is unclear when considering the observed J-shaped associations. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020219808.

Original languageEnglish
Pages (from-to)755-763
Number of pages9
JournalBritish journal of sports medicine
Volume56
Issue number13
DOIs
Publication statusPublished - 2022 Jul 1

Keywords

  • cardiovascular diseases
  • cohort studies
  • meta-analysis
  • survival
  • weight lifting

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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