Mutational analyses of neighboring domains of active center of RNase P ribozyme.

Terumichi Tanaka, Shinnosuke Haga, Naomi Kanda, Tomoaki Ando, Yo Kikuchi

Research output: Contribution to journalArticle

Abstract

We prepared series of P2-P4 domain variants of Escherichia coli ribonuclease P (RNase P) ribozyme, and examined enzymatic activities of them. The results indicated that mutations in these domains did not affect the cleavage site selection of the enzyme, but affected cleavage efficiencies and dependence on magnesium ion concentrations.

Original languageEnglish
Pages (from-to)201-202
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number48
Publication statusPublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Tanaka, T., Haga, S., Kanda, N., Ando, T., & Kikuchi, Y. (2004). Mutational analyses of neighboring domains of active center of RNase P ribozyme. Nucleic acids symposium series (2004), (48), 201-202.