Myelin Measurement: Comparison between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods

Akifumi Hagiwara, Masaaki Hori, Koji Kamagata, Marcel Warntjes, Daisuke Matsuyoshi, Misaki Nakazawa, Ryo Ueda, Christina Andica, Saori Koshino, Tomoko Maekawa, Ryusuke Irie, Tomohiro Takamura, Kanako Kunishima Kumamaru, Osamu Abe, Shigeki Aoki

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Abstract

Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R1 and R2 relaxation rates and proton density (SyMRI) and the ratio of T1-weighted to T2-weighted images (T1w/T2w ratio), were also proposed as methods for measuring myelin. SyMRI and MT imaging have been reported to correlate well with actual myelin by histology. However, for T1w/T2w ratio, such evidence is limited. In 20 healthy adults, we examined the correlation between these three methods, using MT saturation index (MTsat) for MT imaging. After calibration, white matter (WM) to gray matter (GM) contrast was the highest for SyMRI among these three metrics. Even though SyMRI and MTsat showed strong correlation in the WM (r = 0.72), only weak correlation was found between T1w/T2w and SyMRI (r = 0.45) or MTsat (r = 0.38) (correlation coefficients significantly different from each other, with p values < 0.001). In subcortical and cortical GM, these measurements showed moderate to strong correlations to each other (r = 0.54 to 0.78). In conclusion, the high correlation between SyMRI and MTsat indicates that both methods are similarly suited to measure myelin in the WM, whereas T1w/T2w ratio may be less optimal.

Original languageEnglish
Article number10554
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

ASJC Scopus subject areas

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    Hagiwara, A., Hori, M., Kamagata, K., Warntjes, M., Matsuyoshi, D., Nakazawa, M., Ueda, R., Andica, C., Koshino, S., Maekawa, T., Irie, R., Takamura, T., Kumamaru, K. K., Abe, O., & Aoki, S. (2018). Myelin Measurement: Comparison between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods. Scientific Reports, 8(1), [10554]. https://doi.org/10.1038/s41598-018-28852-6