Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions

Daisuke Sasaki; Norio Fukuda; Shin'ichi Ishiwata

doi:10.1016/j.bbrc.2006.03.070

Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions

Daisuke Sasaki, Norio Fukuda, Shin'ichi Ishiwata

Research output: Contribution to journal › Article

21 Citations (Scopus)

Abstract

During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca²⁺ concentration. On the other hand, when intermediately activated at a certain Ca²⁺ concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca²⁺ concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo.

Original language	English
Pages (from-to)	1146-1152
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	343
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2006.03.070
Publication status	Published - 2006 May 19

Keywords

Cardiac muscle
Microscopy
Myocardium
Oscillation
SPOC

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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Sasaki, D., Fukuda, N., & Ishiwata, S. (2006). Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions. Biochemical and Biophysical Research Communications, 343(4), 1146-1152. https://doi.org/10.1016/j.bbrc.2006.03.070

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abstract = "During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca2+ concentration. On the other hand, when intermediately activated at a certain Ca2+ concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca2+ concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo.",

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