Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions

Daisuke Sasaki, Norio Fukuda, Shin'ichi Ishiwata

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca2+ concentration. On the other hand, when intermediately activated at a certain Ca2+ concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca2+ concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo.

    Original languageEnglish
    Pages (from-to)1146-1152
    Number of pages7
    JournalBiochemical and Biophysical Research Communications
    Volume343
    Issue number4
    DOIs
    Publication statusPublished - 2006 May 19

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    Sarcomeres
    Myofibrils
    Myocardium
    Animals
    Rats
    Swine
    Rabbits

    Keywords

    • Cardiac muscle
    • Microscopy
    • Myocardium
    • Oscillation
    • SPOC

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions. / Sasaki, Daisuke; Fukuda, Norio; Ishiwata, Shin'ichi.

    In: Biochemical and Biophysical Research Communications, Vol. 343, No. 4, 19.05.2006, p. 1146-1152.

    Research output: Contribution to journalArticle

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