Abstract
During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca2+ concentration. On the other hand, when intermediately activated at a certain Ca2+ concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca2+ concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 1146-1152 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 343 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2006 May 19 |
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Keywords
- Cardiac muscle
- Microscopy
- Myocardium
- Oscillation
- SPOC
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions. / Sasaki, Daisuke; Fukuda, Norio; Ishiwata, Shin'ichi.
In: Biochemical and Biophysical Research Communications, Vol. 343, No. 4, 19.05.2006, p. 1146-1152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions
AU - Sasaki, Daisuke
AU - Fukuda, Norio
AU - Ishiwata, Shin'ichi
PY - 2006/5/19
Y1 - 2006/5/19
N2 - During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca2+ concentration. On the other hand, when intermediately activated at a certain Ca2+ concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca2+ concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo.
AB - During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca2+ concentration. On the other hand, when intermediately activated at a certain Ca2+ concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca2+ concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo.
KW - Cardiac muscle
KW - Microscopy
KW - Myocardium
KW - Oscillation
KW - SPOC
UR - http://www.scopus.com/inward/record.url?scp=33646026123&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646026123&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2006.03.070
DO - 10.1016/j.bbrc.2006.03.070
M3 - Article
C2 - 16579966
AN - SCOPUS:33646026123
VL - 343
SP - 1146
EP - 1152
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -