Myosin V walks by lever action and Bownian motion

Katsuyuki Shiroguchi, Kazuhiko Kinosita

    Research output: Contribution to journalArticle

    95 Citations (Scopus)

    Abstract

    Myosin V is a molecular motor that moves cargo along actin filaments. Its two heads, each attached to a long and relatively stiff neck, move alternately forward in a "hand-over-hand" fashion. To observe under a microscope how the necks move, we attached a micrometer-sized rod to one of the necks. The leading neck swings undirectionally forward, whereas the trailing neck, once lifted, undergoes extensive Brownian rotation in all directions before landing on a she ahead of the leading head. The neck-neck joint is essentially free, and the neck motion supports a mechanism where the active swing of the leading neck biases the random motion of the lifted head to let it eventually land on a forward site.

    Original languageEnglish
    Pages (from-to)1208-1212
    Number of pages5
    JournalScience
    Volume316
    Issue number5828
    DOIs
    Publication statusPublished - 2007 May 25

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    Myosin Type V
    Neck
    Head
    Hand
    Actin Cytoskeleton
    Joints

    ASJC Scopus subject areas

    • General

    Cite this

    Shiroguchi, K., & Kinosita, K. (2007). Myosin V walks by lever action and Bownian motion. Science, 316(5828), 1208-1212. https://doi.org/10.1126/science.1140468

    Myosin V walks by lever action and Bownian motion. / Shiroguchi, Katsuyuki; Kinosita, Kazuhiko.

    In: Science, Vol. 316, No. 5828, 25.05.2007, p. 1208-1212.

    Research output: Contribution to journalArticle

    Shiroguchi, K & Kinosita, K 2007, 'Myosin V walks by lever action and Bownian motion', Science, vol. 316, no. 5828, pp. 1208-1212. https://doi.org/10.1126/science.1140468
    Shiroguchi, Katsuyuki ; Kinosita, Kazuhiko. / Myosin V walks by lever action and Bownian motion. In: Science. 2007 ; Vol. 316, No. 5828. pp. 1208-1212.
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