N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647

Julius Adam V. Lopez, Toshihiko Nogawa, Yushi Futamura, Harumi Aono, Daisuke Hashizume, Hiroyuki Osada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

N-acetyl-α-hydroxy-β-oxotryptamine (1) along with N-acetyl-β-oxotryptamine (2) and pimprinine (3) were isolated from the culture broth of Streptomyces sp. 80H647. Compound 1 was found to be a racemate via X-ray diffraction analysis and the enantiomers were successfully purified by chiral-phase HPLC. The absolute configuration was assigned by comparison of the calculated and experimental ECD spectra. The α-hydroxy moiety of 1 was vital for cytotoxicity against different cancer cell lines.

Original languageEnglish
Pages (from-to)477-479
Number of pages3
JournalJournal of Antibiotics
Volume74
Issue number7
DOIs
Publication statusPublished - 2021 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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