TY - JOUR
T1 - N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647
AU - Lopez, Julius Adam V.
AU - Nogawa, Toshihiko
AU - Futamura, Yushi
AU - Aono, Harumi
AU - Hashizume, Daisuke
AU - Osada, Hiroyuki
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2021/7
Y1 - 2021/7
N2 - N-acetyl-α-hydroxy-β-oxotryptamine (1) along with N-acetyl-β-oxotryptamine (2) and pimprinine (3) were isolated from the culture broth of Streptomyces sp. 80H647. Compound 1 was found to be a racemate via X-ray diffraction analysis and the enantiomers were successfully purified by chiral-phase HPLC. The absolute configuration was assigned by comparison of the calculated and experimental ECD spectra. The α-hydroxy moiety of 1 was vital for cytotoxicity against different cancer cell lines.
AB - N-acetyl-α-hydroxy-β-oxotryptamine (1) along with N-acetyl-β-oxotryptamine (2) and pimprinine (3) were isolated from the culture broth of Streptomyces sp. 80H647. Compound 1 was found to be a racemate via X-ray diffraction analysis and the enantiomers were successfully purified by chiral-phase HPLC. The absolute configuration was assigned by comparison of the calculated and experimental ECD spectra. The α-hydroxy moiety of 1 was vital for cytotoxicity against different cancer cell lines.
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U2 - 10.1038/s41429-021-00420-7
DO - 10.1038/s41429-021-00420-7
M3 - Article
C2 - 33879862
AN - SCOPUS:85104746099
SN - 0021-8820
VL - 74
SP - 477
EP - 479
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 7
ER -