N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Yukiko Nisikawa, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

    Original languageEnglish
    Pages (from-to)303-305
    Number of pages3
    JournalBrain Research
    Volume782
    Issue number1-2
    DOIs
    Publication statusPublished - 1998 Jan 26

    Fingerprint

    Suprachiasmatic Nucleus
    Long-Term Potentiation
    N-Methyl-D-Aspartate Receptors
    6-Cyano-7-nitroquinoxaline-2,3-dione
    Synaptic Potentials
    Optic Nerve
    Acids
    In Vitro Techniques

    Keywords

    • Long-term potentiation
    • N-Methyl-D-aspartate receptor
    • NMDA receptor
    • Suprachiasmatic nucleus
    • Synaptic potential

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro. / Nisikawa, Yukiko; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.

    In: Brain Research, Vol. 782, No. 1-2, 26.01.1998, p. 303-305.

    Research output: Contribution to journalArticle

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    AU - Watanabe, Shigenori

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