N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization

Takanori Abe; Masaki Kojima; Satoshi Akanuma; Hiromi Iwashita; Takashi Yamazaki; Ryuichi Okuyama; Kenji Ichikawa; Mariko Umemura; Haruo Nakano; Shigeru Takahashi; Yuji Takahashi

doi:10.1074/jbc.M113.491217

N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization

Takanori Abe, Masaki Kojima, Satoshi Akanuma, Hiromi Iwashita, Takashi Yamazaki, Ryuichi Okuyama, Kenji Ichikawa, Mariko Umemura, Haruo Nakano, Shigeru Takahashi^*, Yuji Takahashi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: The N-terminal region of ATF5 is responsible for its CdCl2- and NaAsO2-induced expression. Results: IL-1β stabilizes ATF5 protein and elevates the translation efficiency of ATF5 mRNA. Conclusion: The N-terminal hydrophobic amino acids of ATF5 are important for protein stabilization and responsiveness to IL-1β. Significance: This study provides new insights about the roles of ATF5 in immune response.

Original language	English
Pages (from-to)	3888-3900
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.491217
Publication status	Published - 2014 Feb 14
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Abe, T., Kojima, M., Akanuma, S., Iwashita, H., Yamazaki, T., Okuyama, R., Ichikawa, K., Umemura, M., Nakano, H., Takahashi, S., & Takahashi, Y. (2014). N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization. Journal of Biological Chemistry, 289(7), 3888-3900. https://doi.org/10.1074/jbc.M113.491217

Abe, T, Kojima, M, Akanuma, S, Iwashita, H, Yamazaki, T, Okuyama, R, Ichikawa, K, Umemura, M, Nakano, H, Takahashi, S & Takahashi, Y 2014, 'N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization', Journal of Biological Chemistry, vol. 289, no. 7, pp. 3888-3900. https://doi.org/10.1074/jbc.M113.491217

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abstract = "Background: The N-terminal region of ATF5 is responsible for its CdCl2- and NaAsO2-induced expression. Results: IL-1β stabilizes ATF5 protein and elevates the translation efficiency of ATF5 mRNA. Conclusion: The N-terminal hydrophobic amino acids of ATF5 are important for protein stabilization and responsiveness to IL-1β. Significance: This study provides new insights about the roles of ATF5 in immune response.",

author = "Takanori Abe and Masaki Kojima and Satoshi Akanuma and Hiromi Iwashita and Takashi Yamazaki and Ryuichi Okuyama and Kenji Ichikawa and Mariko Umemura and Haruo Nakano and Shigeru Takahashi and Yuji Takahashi",

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doi = "10.1074/jbc.M113.491217",

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T1 - N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization

AU - Abe, Takanori

AU - Kojima, Masaki

AU - Akanuma, Satoshi

AU - Iwashita, Hiromi

AU - Yamazaki, Takashi

AU - Okuyama, Ryuichi

AU - Ichikawa, Kenji

AU - Umemura, Mariko

AU - Nakano, Haruo

AU - Takahashi, Shigeru

AU - Takahashi, Yuji

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: The N-terminal region of ATF5 is responsible for its CdCl2- and NaAsO2-induced expression. Results: IL-1β stabilizes ATF5 protein and elevates the translation efficiency of ATF5 mRNA. Conclusion: The N-terminal hydrophobic amino acids of ATF5 are important for protein stabilization and responsiveness to IL-1β. Significance: This study provides new insights about the roles of ATF5 in immune response.

AB - Background: The N-terminal region of ATF5 is responsible for its CdCl2- and NaAsO2-induced expression. Results: IL-1β stabilizes ATF5 protein and elevates the translation efficiency of ATF5 mRNA. Conclusion: The N-terminal hydrophobic amino acids of ATF5 are important for protein stabilization and responsiveness to IL-1β. Significance: This study provides new insights about the roles of ATF5 in immune response.

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N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization

Abstract

ASJC Scopus subject areas

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