N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization

Takanori Abe, Masaki Kojima, Satoshi Akanuma, Hiromi Iwashita, Takashi Yamazaki, Ryuichi Okuyama, Kenji Ichikawa, Mariko Umemura, Haruo Nakano, Shigeru Takahashi, Yuji Takahashi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The N-terminal region of ATF5 is responsible for its CdCl2- and NaAsO2-induced expression. Results: IL-1β stabilizes ATF5 protein and elevates the translation efficiency of ATF5 mRNA. Conclusion: The N-terminal hydrophobic amino acids of ATF5 are important for protein stabilization and responsiveness to IL-1β. Significance: This study provides new insights about the roles of ATF5 in immune response.

Original languageEnglish
Pages (from-to)3888-3900
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
Publication statusPublished - 2014 Feb 14
Externally publishedYes

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Activating Transcription Factors
Interleukin-1
Stabilization
Amino Acids
Proteins
Cadmium Chloride
Protein Biosynthesis
Messenger RNA

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization. / Abe, Takanori; Kojima, Masaki; Akanuma, Satoshi; Iwashita, Hiromi; Yamazaki, Takashi; Okuyama, Ryuichi; Ichikawa, Kenji; Umemura, Mariko; Nakano, Haruo; Takahashi, Shigeru; Takahashi, Yuji.

In: Journal of Biological Chemistry, Vol. 289, No. 7, 14.02.2014, p. 3888-3900.

Research output: Contribution to journalArticle

Abe, T, Kojima, M, Akanuma, S, Iwashita, H, Yamazaki, T, Okuyama, R, Ichikawa, K, Umemura, M, Nakano, H, Takahashi, S & Takahashi, Y 2014, 'N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization', Journal of Biological Chemistry, vol. 289, no. 7, pp. 3888-3900. https://doi.org/10.1074/jbc.M113.491217
Abe, Takanori ; Kojima, Masaki ; Akanuma, Satoshi ; Iwashita, Hiromi ; Yamazaki, Takashi ; Okuyama, Ryuichi ; Ichikawa, Kenji ; Umemura, Mariko ; Nakano, Haruo ; Takahashi, Shigeru ; Takahashi, Yuji. / N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 7. pp. 3888-3900.
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AU - Iwashita, Hiromi

AU - Yamazaki, Takashi

AU - Okuyama, Ryuichi

AU - Ichikawa, Kenji

AU - Umemura, Mariko

AU - Nakano, Haruo

AU - Takahashi, Shigeru

AU - Takahashi, Yuji

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