Background: The N-terminal region of ATF5 is responsible for its CdCl2- and NaAsO2-induced expression. Results: IL-1β stabilizes ATF5 protein and elevates the translation efficiency of ATF5 mRNA. Conclusion: The N-terminal hydrophobic amino acids of ATF5 are important for protein stabilization and responsiveness to IL-1β. Significance: This study provides new insights about the roles of ATF5 in immune response.
|Number of pages||13|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 2014 Feb 14|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology