Nanofluidic Strategies for Cancer Research

Miao Wang, Po Jung Huang, Jun Kameoka, Chao Kai Chou, Pei Hsiang Tsou, Hirohito Yamaguchi, Mien Chie Hung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nanofluidic system can be used as powerful tool for detecting single molecules through fluorescence correlation spectroscopy (FCS). Several types of nanofluidic channels, such as hollow nanofibres or nanotrenches, can be constructed on quartz wafers, though electrospinning and nanolithography, respectively. The advantages of nanofluidic channels in molecule detection are not only in reducing the amount of volume of analyte, but also for improving electrokinetic molecule transport. Therefore, small molecules, like proteins or DNA, can be detected in nanochannels. Furthermore, nanofluidic channels can be used to monitor protein-protein, post translational modification, protein-DNA, and protein-RNA interactions, which rely on labelling proteins of interest within fluorescent molecules, in tissue samples directly. Based on these results, nanofluidic channels can be used in diagnostic application for early diagnosis of cancers and drug screenings.

Original languageEnglish
Title of host publicationNanofluidics, 2nd Edition
EditorsPaul O'Brien, Joshua Edel, Aleksandar Ivanov, MinJun Kim
PublisherRoyal Society of Chemistry
Pages114-149
Number of pages36
Edition41
ISBN (Electronic)9781782621713, 9781849734042
DOIs
Publication statusPublished - 2017
Externally publishedYes

Publication series

NameRSC Nanoscience and Nanotechnology
Number41
Volume2017-January
ISSN (Print)1757-7136
ISSN (Electronic)1757-7144

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)
  • Engineering(all)

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