Nanoscopic behavior of polyvinylpyrrolidone particles on polysulfone/polyvinylpyrrolidone film

Masayo Hayama, Ken Ichiro Yamamoto, Fukashi Kohori, Tsutomu Uesaka, Yoshiyuki Ueno, Hiroyuki Sugaya, Ichiro Itagaki, Kiyotaka Sakai

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    70 Citations (Scopus)


    We revealed morphology and physicochemical behavior of a widely used powerful hydrophilizing agent, polyvinylpyrrolidone (PVP), present on polysulfone (PS)/PVP films by atomic force microscopy (AFM). This is the first time such clear PS/PVP phase-separated morphology was observed by nanoscopic technique. The film surfaces were observed by the identical observation mode, probe and scanning conditions to reveal the change of PVP morphology and behavior between dry and wet conditions. Morphology was related to biocompatibility by combining AFM data with results of surface element composition, contact angle, adhesion amount of rabbit platelet and relative amount of adsorbed fibrinogen. PVP nano-particles of one or several molecules were formed on the dry PS/PVP film surfaces. Amount of PVP present on the surfaces increased with the molecular weight of PVP. At a mixed amount of 1-5wt%, PVP K90 formed crowded particles on the dry surface. When wet, they swelled, followed by their union to produce a smooth surface leading to improved biocompatibility. The highest biocompatibility with excellent mechanical strength is achieved by blending the highest molecular weight PVP K90 at 1-5wt%.

    Original languageEnglish
    Pages (from-to)1019-1028
    Number of pages10
    Issue number6
    Publication statusPublished - 2004 Mar



    • Atomic force microscopy
    • Biocompatibility
    • Polysulfone/PVP films
    • PVP nanoparticles
    • Surface analysis
    • Surface roughness

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Biomedical Engineering

    Cite this

    Hayama, M., Yamamoto, K. I., Kohori, F., Uesaka, T., Ueno, Y., Sugaya, H., Itagaki, I., & Sakai, K. (2004). Nanoscopic behavior of polyvinylpyrrolidone particles on polysulfone/polyvinylpyrrolidone film. Biomaterials, 25(6), 1019-1028.