Network-dependent modulation of brain activity during sleep

Takamitsu Watanabe*, Shigeyuki Kan, Takahiko Koike, Masaya Misaki, Seiki Konishi, Satoru Miyauchi, Yasushi Miyahsita, Naoki Masuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Brain activity dynamically changes even during sleep. A line of neuroimaging studies has reported changes in functional connectivity and regional activity across different sleep stages such as slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep. However, it remains unclear whether and how the large-scale network activity of human brains changes within a given sleep stage. Here, we investigated modulation of network activity within sleep stages by applying the pairwise maximum entropy model to brain activity obtained by functional magnetic resonance imaging from sleeping healthy subjects. We found that the brain activity of individual brain regions and functional interactions between pairs of regions significantly increased in the default-mode network during SWS and decreased during REM sleep. In contrast, the network activity of the fronto-parietal and sensory-motor networks showed the opposite pattern. Furthermore, in the three networks, the amount of the activity changes throughout REM sleep was negatively correlated with that throughout SWS. The present findings suggest that the brain activity is dynamically modulated even in a sleep stage and that the pattern of modulation depends on the type of the large-scale brain networks.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalNeuroImage
Volume98
DOIs
Publication statusPublished - 2014 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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