Neural basis for the relationship between frequency of going outdoors and depressive mood in older adults

Ryota Sakurai, Hiroyuki Suzuki, Yoshinori Fujiwara, Masashi Yasunaga, Rumi Takeuchi, Yoh Murayama, Kimi Estela Kobayashi Cuya, Kazuyuki Kanosue, Kenji Ishii

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Low frequency of going outdoors (e.g. being homebound) is associated with depressive mood; however, the underlying neural mechanism of this association is unclear. We therefore investigated the neural substrate involved in the relationship between frequency of going outdoors and depressive mood using positron emission tomography (PET), focusing on the frontal lobe and the limbic system. Methods: One hundred fifty-eight community-dwelling older adults aged 65-85years underwent PET with 18F-fluorodeoxyglucose to evaluate regional cerebral metabolic rates of glucose normalized in reference to cerebellar glucose metabolic value (normalized-rCMRglc) in six regions of interest. We also assessed depressive mood, frequency of going outdoors, and potential covariates. Depressive mood was assessed using the Geriatric Depression Scale (GDS). Results: The proportion of participants who reported low frequency of going outdoors (LG, every 2-3days or less) was 36.1%. The LG group showed significantly higher GDS scores than those who reported high (once a day or more) frequency of going outdoors. A multiple linear regression analysis adjusted for potential covariates showed higher GDS scores were associated with lower normalized-rCMRglc in the ventrolateral prefrontal and orbitofrontal cortices. Adjusting for frequency of going outdoors, the association between GDS score and normalized-rCMRglc in the orbitofrontal cortex was attenuated. Conclusions: Our results suggest that the orbitofrontal cortex may mediate the relationship between low frequency of going outdoors and depressive mood among community-dwelling older adults. These findings may help disentangle the role of going outdoors in regulating brain function to improve and/or maintain mental health among community-dwelling older adults.

Original languageEnglish
JournalInternational Journal of Geriatric Psychiatry
DOIs
Publication statusAccepted/In press - 2016

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Prefrontal Cortex
Independent Living
Geriatrics
Depression
Positron-Emission Tomography
Glucose
Limbic System
Fluorodeoxyglucose F18
Frontal Lobe
Linear Models
Mental Health
Regression Analysis
Brain

Keywords

  • Depressive mood
  • FDG-PET
  • Older adults
  • Orbitofrontal cortex
  • Physical activity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Neural basis for the relationship between frequency of going outdoors and depressive mood in older adults. / Sakurai, Ryota; Suzuki, Hiroyuki; Fujiwara, Yoshinori; Yasunaga, Masashi; Takeuchi, Rumi; Murayama, Yoh; Cuya, Kimi Estela Kobayashi; Kanosue, Kazuyuki; Ishii, Kenji.

In: International Journal of Geriatric Psychiatry, 2016.

Research output: Contribution to journalArticle

Sakurai, Ryota ; Suzuki, Hiroyuki ; Fujiwara, Yoshinori ; Yasunaga, Masashi ; Takeuchi, Rumi ; Murayama, Yoh ; Cuya, Kimi Estela Kobayashi ; Kanosue, Kazuyuki ; Ishii, Kenji. / Neural basis for the relationship between frequency of going outdoors and depressive mood in older adults. In: International Journal of Geriatric Psychiatry. 2016.
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abstract = "Objective: Low frequency of going outdoors (e.g. being homebound) is associated with depressive mood; however, the underlying neural mechanism of this association is unclear. We therefore investigated the neural substrate involved in the relationship between frequency of going outdoors and depressive mood using positron emission tomography (PET), focusing on the frontal lobe and the limbic system. Methods: One hundred fifty-eight community-dwelling older adults aged 65-85years underwent PET with 18F-fluorodeoxyglucose to evaluate regional cerebral metabolic rates of glucose normalized in reference to cerebellar glucose metabolic value (normalized-rCMRglc) in six regions of interest. We also assessed depressive mood, frequency of going outdoors, and potential covariates. Depressive mood was assessed using the Geriatric Depression Scale (GDS). Results: The proportion of participants who reported low frequency of going outdoors (LG, every 2-3days or less) was 36.1{\%}. The LG group showed significantly higher GDS scores than those who reported high (once a day or more) frequency of going outdoors. A multiple linear regression analysis adjusted for potential covariates showed higher GDS scores were associated with lower normalized-rCMRglc in the ventrolateral prefrontal and orbitofrontal cortices. Adjusting for frequency of going outdoors, the association between GDS score and normalized-rCMRglc in the orbitofrontal cortex was attenuated. Conclusions: Our results suggest that the orbitofrontal cortex may mediate the relationship between low frequency of going outdoors and depressive mood among community-dwelling older adults. These findings may help disentangle the role of going outdoors in regulating brain function to improve and/or maintain mental health among community-dwelling older adults.",
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AU - Sakurai, Ryota

AU - Suzuki, Hiroyuki

AU - Fujiwara, Yoshinori

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AU - Takeuchi, Rumi

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AU - Cuya, Kimi Estela Kobayashi

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AU - Ishii, Kenji

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N2 - Objective: Low frequency of going outdoors (e.g. being homebound) is associated with depressive mood; however, the underlying neural mechanism of this association is unclear. We therefore investigated the neural substrate involved in the relationship between frequency of going outdoors and depressive mood using positron emission tomography (PET), focusing on the frontal lobe and the limbic system. Methods: One hundred fifty-eight community-dwelling older adults aged 65-85years underwent PET with 18F-fluorodeoxyglucose to evaluate regional cerebral metabolic rates of glucose normalized in reference to cerebellar glucose metabolic value (normalized-rCMRglc) in six regions of interest. We also assessed depressive mood, frequency of going outdoors, and potential covariates. Depressive mood was assessed using the Geriatric Depression Scale (GDS). Results: The proportion of participants who reported low frequency of going outdoors (LG, every 2-3days or less) was 36.1%. The LG group showed significantly higher GDS scores than those who reported high (once a day or more) frequency of going outdoors. A multiple linear regression analysis adjusted for potential covariates showed higher GDS scores were associated with lower normalized-rCMRglc in the ventrolateral prefrontal and orbitofrontal cortices. Adjusting for frequency of going outdoors, the association between GDS score and normalized-rCMRglc in the orbitofrontal cortex was attenuated. Conclusions: Our results suggest that the orbitofrontal cortex may mediate the relationship between low frequency of going outdoors and depressive mood among community-dwelling older adults. These findings may help disentangle the role of going outdoors in regulating brain function to improve and/or maintain mental health among community-dwelling older adults.

AB - Objective: Low frequency of going outdoors (e.g. being homebound) is associated with depressive mood; however, the underlying neural mechanism of this association is unclear. We therefore investigated the neural substrate involved in the relationship between frequency of going outdoors and depressive mood using positron emission tomography (PET), focusing on the frontal lobe and the limbic system. Methods: One hundred fifty-eight community-dwelling older adults aged 65-85years underwent PET with 18F-fluorodeoxyglucose to evaluate regional cerebral metabolic rates of glucose normalized in reference to cerebellar glucose metabolic value (normalized-rCMRglc) in six regions of interest. We also assessed depressive mood, frequency of going outdoors, and potential covariates. Depressive mood was assessed using the Geriatric Depression Scale (GDS). Results: The proportion of participants who reported low frequency of going outdoors (LG, every 2-3days or less) was 36.1%. The LG group showed significantly higher GDS scores than those who reported high (once a day or more) frequency of going outdoors. A multiple linear regression analysis adjusted for potential covariates showed higher GDS scores were associated with lower normalized-rCMRglc in the ventrolateral prefrontal and orbitofrontal cortices. Adjusting for frequency of going outdoors, the association between GDS score and normalized-rCMRglc in the orbitofrontal cortex was attenuated. Conclusions: Our results suggest that the orbitofrontal cortex may mediate the relationship between low frequency of going outdoors and depressive mood among community-dwelling older adults. These findings may help disentangle the role of going outdoors in regulating brain function to improve and/or maintain mental health among community-dwelling older adults.

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