Neural Electrodes Based on 3D Organic Electroactive Microfibers

Jason B. Marroquin, Harold A. Coleman, Mary A. Tonta, Kun Zhou, Bjorn Winther Jensen, James Fallon, Noel W. Duffy, Edwin Yan, Ammar A. Abdulwahid, Jacek J. Jasieniak, John S. Forsythe, Helena C. Parkington

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Neural electrodes used for in vivo biomedical applications (e.g., prostheses, bionic implants) result in glial invasion, leading to the formation of a nonexcitable scar that increases the distance between neurons and electrode and increases the resistance to current flow. The result is progressive deterioration in the performance of stimulation or recording of neural activity and inevitable device failure. Also, electrodes with a 2D surface have a limited proximity to neurons. In the present study, a macroporous and fibrous 3D neural electrode is developed using poly-L-lactic acid fibrous membranes imbued with electroactive properties via a coating of the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT), using vapor phase polymerization. The electrical properties of the PEDOT-coated substrates are studied using sheet resistance and impedance. PEDOT electrode biocompatibility is assessed through in vitro assays using patch-clamp electrophysiology and calcium imaging of isolated and cultured rat hippocampal neurons. PEDOT fibers support robust normal functional development of neurons, including synaptic networking and communication. Stimulation and recording of activity in brain slices and from the surface of the brain using 3D-PEDOT fibrous electrodes are indistinguishable from recordings using conventional glass or platinum electrodes. In vivo studies reveal minimal reactive gliosis in response to electrode implantation.

    Original languageEnglish
    Article number1700927
    JournalAdvanced Functional Materials
    Volume28
    Issue number12
    DOIs
    Publication statusPublished - 2018 Mar 21

    Fingerprint

    microfibers
    Electrodes
    electrodes
    neurons
    Neurons
    recording
    stimulation
    brain
    Brain
    Fibrous membranes
    electrophysiology
    Electrophysiology
    glass electrodes
    bionics
    Bionics
    scars
    clamps
    lactic acid
    Sheet resistance
    Clamping devices

    Keywords

    • electrophysiology
    • neural electrodes
    • neural interfaces
    • poly(3,4-ethylenedioxythiophene) (PEDOT)

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Condensed Matter Physics
    • Electrochemistry

    Cite this

    Marroquin, J. B., Coleman, H. A., Tonta, M. A., Zhou, K., Winther Jensen, B., Fallon, J., ... Parkington, H. C. (2018). Neural Electrodes Based on 3D Organic Electroactive Microfibers. Advanced Functional Materials, 28(12), [1700927]. https://doi.org/10.1002/adfm.201700927

    Neural Electrodes Based on 3D Organic Electroactive Microfibers. / Marroquin, Jason B.; Coleman, Harold A.; Tonta, Mary A.; Zhou, Kun; Winther Jensen, Bjorn; Fallon, James; Duffy, Noel W.; Yan, Edwin; Abdulwahid, Ammar A.; Jasieniak, Jacek J.; Forsythe, John S.; Parkington, Helena C.

    In: Advanced Functional Materials, Vol. 28, No. 12, 1700927, 21.03.2018.

    Research output: Contribution to journalArticle

    Marroquin, JB, Coleman, HA, Tonta, MA, Zhou, K, Winther Jensen, B, Fallon, J, Duffy, NW, Yan, E, Abdulwahid, AA, Jasieniak, JJ, Forsythe, JS & Parkington, HC 2018, 'Neural Electrodes Based on 3D Organic Electroactive Microfibers', Advanced Functional Materials, vol. 28, no. 12, 1700927. https://doi.org/10.1002/adfm.201700927
    Marroquin, Jason B. ; Coleman, Harold A. ; Tonta, Mary A. ; Zhou, Kun ; Winther Jensen, Bjorn ; Fallon, James ; Duffy, Noel W. ; Yan, Edwin ; Abdulwahid, Ammar A. ; Jasieniak, Jacek J. ; Forsythe, John S. ; Parkington, Helena C. / Neural Electrodes Based on 3D Organic Electroactive Microfibers. In: Advanced Functional Materials. 2018 ; Vol. 28, No. 12.
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