Neuronal circuitries involved in thermoregulation

Kei Nagashima, Sadamu Nakai, Mutsumi Tanaka, Kazuyuki Kanosue

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

The body temperature of homeothermic animals is regulated by systems that utilize multiple behavioral and autonomic effector responses. In the last few years, new approaches have brought us new information and new ideas about neuronal interconnections in the thermoregulatory network. Studies utilizing chemical stimulation of the preoptic area revealed both heat loss and production responses are controlled by warm-sensitive neurons. These neurons send excitatory efferent signals for the heat loss and inhibitory efferent signals for the heat production. The warm-sensitive neurons are separated and work independently to control these two opposing responses. Recent electrophysiological analysis have identified some neurons sending axons directly to the spinal cord for thermoregulatory effector control. Included are midbrain reticulospinal neurons for shivering and premotor neurons in the medulla oblongata for skin vasomotor control. As for the afferent side of the thermoregulatory network, the vagus nerve is recently paid much attention, which would convey signals for peripheral infection to the brain and be responsible for the induction of fever. The vagus nerve may also participate in thermoregulation in afebrile conditions, because some substances such as cholecyctokinin and leptin activate the vagus nerve. Although the functional role for this response is still obscure, the vagus may transfer nutritional and/or metabolic signals to the brain, affecting metabolism and body temperature. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalAutonomic Neuroscience: Basic and Clinical
Volume85
Issue number1-3
DOIs
Publication statusPublished - 2000 Dec 20
Externally publishedYes

Fingerprint

Body Temperature Regulation
Neurons
Vagus Nerve
Thermogenesis
Body Temperature
Chemical Stimulation
Shivering
Medulla Oblongata
Preoptic Area
Brain
Mesencephalon
Leptin
Axons
Spinal Cord
Fever
Hot Temperature
Skin
Infection

Keywords

  • Body temperature
  • Efferent pathway
  • Hypothalamus
  • Preoptic area
  • Vagus nerve

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Neuronal circuitries involved in thermoregulation. / Nagashima, Kei; Nakai, Sadamu; Tanaka, Mutsumi; Kanosue, Kazuyuki.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 85, No. 1-3, 20.12.2000, p. 18-25.

Research output: Contribution to journalArticle

@article{98faa380c46045d39cf8d2f8eeb7fb54,
title = "Neuronal circuitries involved in thermoregulation",
abstract = "The body temperature of homeothermic animals is regulated by systems that utilize multiple behavioral and autonomic effector responses. In the last few years, new approaches have brought us new information and new ideas about neuronal interconnections in the thermoregulatory network. Studies utilizing chemical stimulation of the preoptic area revealed both heat loss and production responses are controlled by warm-sensitive neurons. These neurons send excitatory efferent signals for the heat loss and inhibitory efferent signals for the heat production. The warm-sensitive neurons are separated and work independently to control these two opposing responses. Recent electrophysiological analysis have identified some neurons sending axons directly to the spinal cord for thermoregulatory effector control. Included are midbrain reticulospinal neurons for shivering and premotor neurons in the medulla oblongata for skin vasomotor control. As for the afferent side of the thermoregulatory network, the vagus nerve is recently paid much attention, which would convey signals for peripheral infection to the brain and be responsible for the induction of fever. The vagus nerve may also participate in thermoregulation in afebrile conditions, because some substances such as cholecyctokinin and leptin activate the vagus nerve. Although the functional role for this response is still obscure, the vagus may transfer nutritional and/or metabolic signals to the brain, affecting metabolism and body temperature. Copyright (C) 2000 Elsevier Science B.V.",
keywords = "Body temperature, Efferent pathway, Hypothalamus, Preoptic area, Vagus nerve",
author = "Kei Nagashima and Sadamu Nakai and Mutsumi Tanaka and Kazuyuki Kanosue",
year = "2000",
month = "12",
day = "20",
doi = "10.1016/S1566-0702(00)00216-2",
language = "English",
volume = "85",
pages = "18--25",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Neuronal circuitries involved in thermoregulation

AU - Nagashima, Kei

AU - Nakai, Sadamu

AU - Tanaka, Mutsumi

AU - Kanosue, Kazuyuki

PY - 2000/12/20

Y1 - 2000/12/20

N2 - The body temperature of homeothermic animals is regulated by systems that utilize multiple behavioral and autonomic effector responses. In the last few years, new approaches have brought us new information and new ideas about neuronal interconnections in the thermoregulatory network. Studies utilizing chemical stimulation of the preoptic area revealed both heat loss and production responses are controlled by warm-sensitive neurons. These neurons send excitatory efferent signals for the heat loss and inhibitory efferent signals for the heat production. The warm-sensitive neurons are separated and work independently to control these two opposing responses. Recent electrophysiological analysis have identified some neurons sending axons directly to the spinal cord for thermoregulatory effector control. Included are midbrain reticulospinal neurons for shivering and premotor neurons in the medulla oblongata for skin vasomotor control. As for the afferent side of the thermoregulatory network, the vagus nerve is recently paid much attention, which would convey signals for peripheral infection to the brain and be responsible for the induction of fever. The vagus nerve may also participate in thermoregulation in afebrile conditions, because some substances such as cholecyctokinin and leptin activate the vagus nerve. Although the functional role for this response is still obscure, the vagus may transfer nutritional and/or metabolic signals to the brain, affecting metabolism and body temperature. Copyright (C) 2000 Elsevier Science B.V.

AB - The body temperature of homeothermic animals is regulated by systems that utilize multiple behavioral and autonomic effector responses. In the last few years, new approaches have brought us new information and new ideas about neuronal interconnections in the thermoregulatory network. Studies utilizing chemical stimulation of the preoptic area revealed both heat loss and production responses are controlled by warm-sensitive neurons. These neurons send excitatory efferent signals for the heat loss and inhibitory efferent signals for the heat production. The warm-sensitive neurons are separated and work independently to control these two opposing responses. Recent electrophysiological analysis have identified some neurons sending axons directly to the spinal cord for thermoregulatory effector control. Included are midbrain reticulospinal neurons for shivering and premotor neurons in the medulla oblongata for skin vasomotor control. As for the afferent side of the thermoregulatory network, the vagus nerve is recently paid much attention, which would convey signals for peripheral infection to the brain and be responsible for the induction of fever. The vagus nerve may also participate in thermoregulation in afebrile conditions, because some substances such as cholecyctokinin and leptin activate the vagus nerve. Although the functional role for this response is still obscure, the vagus may transfer nutritional and/or metabolic signals to the brain, affecting metabolism and body temperature. Copyright (C) 2000 Elsevier Science B.V.

KW - Body temperature

KW - Efferent pathway

KW - Hypothalamus

KW - Preoptic area

KW - Vagus nerve

UR - http://www.scopus.com/inward/record.url?scp=0034695154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034695154&partnerID=8YFLogxK

U2 - 10.1016/S1566-0702(00)00216-2

DO - 10.1016/S1566-0702(00)00216-2

M3 - Article

VL - 85

SP - 18

EP - 25

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 1-3

ER -