Neurosteroid biosynthesis and action during cerebellar development

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. In the middle 1990s, we identified the Purkinje cell, a principal cerebellar neuron, as a major site for neurosteroid formation in mammals. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis and neurosteroid actions on neuronal growth and synaptic formation in the cerebellum. Based on extensive studies on mammals over the past decade, we now know that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This paper highlights the biosynthesis and biological actions of neurosteroids in the Purkinje cell during cerebellar development.

    Original languageEnglish
    Pages (from-to)414-415
    Number of pages2
    JournalCerebellum
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 2012 Jun

    Fingerprint

    Purkinje Cells
    Neurotransmitter Agents
    Progesterone
    Cerebellum
    Mammals
    Estradiol
    Growth
    Pregnanolone
    Cerebellar Cortex
    Nerve Growth Factors
    Cytoplasmic and Nuclear Receptors
    Neuroglia
    Cell Survival
    Cholesterol
    Neurons

    Keywords

    • - Brain-derived neurotrophic factor
    • Allopregnanolone
    • Estradiol
    • Neuronal circuit formation
    • Progesterone
    • Purkinje cell

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

    Cite this

    Neurosteroid biosynthesis and action during cerebellar development. / Tsutsui, Kazuyoshi.

    In: Cerebellum, Vol. 11, No. 2, 06.2012, p. 414-415.

    Research output: Contribution to journalArticle

    @article{a62848e4c65143498ce09a9a2041123b,
    title = "Neurosteroid biosynthesis and action during cerebellar development",
    abstract = "The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. In the middle 1990s, we identified the Purkinje cell, a principal cerebellar neuron, as a major site for neurosteroid formation in mammals. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis and neurosteroid actions on neuronal growth and synaptic formation in the cerebellum. Based on extensive studies on mammals over the past decade, we now know that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This paper highlights the biosynthesis and biological actions of neurosteroids in the Purkinje cell during cerebellar development.",
    keywords = "- Brain-derived neurotrophic factor, Allopregnanolone, Estradiol, Neuronal circuit formation, Progesterone, Purkinje cell",
    author = "Kazuyoshi Tsutsui",
    year = "2012",
    month = "6",
    doi = "10.1007/s12311-011-0341-7",
    language = "English",
    volume = "11",
    pages = "414--415",
    journal = "Cerebellum",
    issn = "1473-4222",
    publisher = "Springer New York",
    number = "2",

    }

    TY - JOUR

    T1 - Neurosteroid biosynthesis and action during cerebellar development

    AU - Tsutsui, Kazuyoshi

    PY - 2012/6

    Y1 - 2012/6

    N2 - The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. In the middle 1990s, we identified the Purkinje cell, a principal cerebellar neuron, as a major site for neurosteroid formation in mammals. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis and neurosteroid actions on neuronal growth and synaptic formation in the cerebellum. Based on extensive studies on mammals over the past decade, we now know that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This paper highlights the biosynthesis and biological actions of neurosteroids in the Purkinje cell during cerebellar development.

    AB - The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. In the middle 1990s, we identified the Purkinje cell, a principal cerebellar neuron, as a major site for neurosteroid formation in mammals. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis and neurosteroid actions on neuronal growth and synaptic formation in the cerebellum. Based on extensive studies on mammals over the past decade, we now know that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This paper highlights the biosynthesis and biological actions of neurosteroids in the Purkinje cell during cerebellar development.

    KW - - Brain-derived neurotrophic factor

    KW - Allopregnanolone

    KW - Estradiol

    KW - Neuronal circuit formation

    KW - Progesterone

    KW - Purkinje cell

    UR - http://www.scopus.com/inward/record.url?scp=84864690494&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84864690494&partnerID=8YFLogxK

    U2 - 10.1007/s12311-011-0341-7

    DO - 10.1007/s12311-011-0341-7

    M3 - Article

    VL - 11

    SP - 414

    EP - 415

    JO - Cerebellum

    JF - Cerebellum

    SN - 1473-4222

    IS - 2

    ER -